Ticagrelor induced systemic inflammatory response syndrome.

Krisai, Philipp; Haschke, Manuel Martin; Buser, Peter T; Mueller, Christian (2017). Ticagrelor induced systemic inflammatory response syndrome. BMC cardiovascular disorders, 17(1), p. 14. BioMed Central 10.1186/s12872-016-0443-8

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BACKGROUND

Ticagrelor is a reversible and direct-acting oral antagonist of the adenosine diphosphate receptor P2Y12. Possible adenosine-mediated effects of ticagrelor on inflammation are complex and incompletely understood. To our knowledge, ticagrelor-induced systemic inflammatory response syndrome (SIRS) has not yet been described.

CASE PRESENTATION

We report the case of an 84 years old patient presenting with SIRS subsequent to initiation of ticagrelor after implantation of two drug eluting stents. A broad diagnostic work-up for alternative causes and therapeutic measures were unrevealing. Discontinuation of the agent was followed by rapid improvement in clinical and laboratory signs of SIRS.

CONCLUSIONS

After exclusion of other causes, ticagrelor needs to be considered as a possible causative agent for SIRS. Due to the widespread use of ticagrelor, clinicians should be aware of this possible adverse drug reaction.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Haschke, Manuel Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1471-2261

Publisher:

BioMed Central

Language:

English

Submitter:

Jacques Donzé

Date Deposited:

21 Mar 2018 15:26

Last Modified:

25 Oct 2019 11:37

Publisher DOI:

10.1186/s12872-016-0443-8

PubMed ID:

28056791

Uncontrolled Keywords:

Adverse drug reaction Case report SIRS Ticagrelor

BORIS DOI:

10.7892/boris.110669

URI:

https://boris.unibe.ch/id/eprint/110669

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