Haschke, Manuel Martin

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Varum, F; Thorne, H; Bravo, R; Gilgen, D; Hartig, C; Nicolas, G P; Wild, D; Liakoni, Ev; Haschke, M (2022). Targeted colonic release formulations of mesalazine - A clinical pharmaco-scintigraphic proof-of-concept study in healthy subjects and patients with mildly active ulcerative colitis. International journal of pharmaceutics, 625, p. 122055. Elsevier 10.1016/j.ijpharm.2022.122055

Duthaler, Urs; Bachmann, Fabio; Suenderhauf, Claudia; Grandinetti, Tanja; Pfefferkorn, Florian; Haschke, Manuel; Hruz, Petr; Bouitbir, Jamal; Krähenbühl, Stephan (2022). Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently. Clinical pharmacokinetics, 61(7), pp. 1039-1055. Springer 10.1007/s40262-022-01119-0

Banholzer, Sarah; Helbling, Arthur; Haschke, Manuel (May 2022). Successful re-exposure to COVID-19 mRNA vaccination at a reduced dosage in a patient with clinically suspected pericarditis/myocarditis after a first dose of COVID-19 vaccine. Swissmedic Vigilance News, pp. 10-13. Swissmedic


Zerah, Lorène; Henrard, Séverine; Wilting, Ingeborg; O'Mahony, Denis; Rodondi, Nicolas; Dalleur, Olivia; Dalton, Kieran; Knol, Wilma; Haschke, Manuel; Spinewine, Anne (2021). Prevalence of drug-drug interactions in older people before and after hospital admission: analysis from the OPERAM trial. BMC Geriatrics, 21(1), p. 571. BioMed Central 10.1186/s12877-021-02532-z

Wertli, Maria Monika; Flury, Julian S; Streit, Sven; Limacher, Andreas; Schuler, Vanessa; Ferrante, Asha-Naima; Rimensberger, Caroline; Haschke, Manuel (2021). Efficacy of metamizole versus ibuprofen and a short educational intervention versus standard care in acute and subacute low back pain: a study protocol of a randomised, multicentre, factorial trial (EMISI trial). BMJ open, 11(10), e048531. BMJ Publishing Group 10.1136/bmjopen-2020-048531

Glinz, Delphine; Bläsi, Claudia; Villiger, Andrea; Meienberg, Andrea; Socrates, Thenral; Pfister, Otmar; Mayr, Michael; Haschke, Manuel; Vischer, Annina Salome; Burkard, Thilo (2021). Hemodynamic profiles in treatment-naive arterial hypertension and their clinical implication for treatment choice: an exploratory post hoc analysis. Journal of hypertension, 39(6), pp. 1246-1253. Wolters Kluwer Health 10.1097/HJH.0000000000002766

Bachmann, Fabio; Duthaler, Urs; Meyer Zu Schwabedissen, Henriette E; Puchkov, Maxim; Huwyler, Jörg; Haschke, Manuel; Krähenbühl, Stephan (2021). Metamizole is a moderate cytochrome P450 inducer via the constitutive androstane receptor and a weak inhibitor of CYP1A2. Clinical pharmacology and therapeutics, 109(6), pp. 1505-1516. Wiley 10.1002/cpt.2141

Vischer, Annina S; Kuster, Gabriela M; Twerenbold, Raphael; Pfister, Otmar; Zhou, Qian; Villiger, Andrea; Poglitsch, Marko; Krähenbühl, Stephan; Mayr, Michael; Osswald, Stefan; Haschke, Manuel; Burkard, Thilo (2021). Influence of Antihypertensive Treatment on RAAS Peptides in Newly Diagnosed Hypertensive Patients. Cells, 10(3) MDPI 10.3390/cells10030534

Scholz, Irene; Liakoni, Evangelia; Hammann, Felix; Grafinger, Katharina Elisabeth; Duthaler, Urs; Nagler, Michael; Krähenbühl, Stephan; Haschke, Manuel (2021). Effects of Hypericum perforatum (St John's wort) on the pharmacokinetics and pharmacodynamics of rivaroxaban in humans. British journal of clinical pharmacology, 87(3), pp. 1466-1474. Wiley-Blackwell 10.1111/bcp.14553

Banholzer, Sarah; Dunkelmann, Lea; Haschke, Manuel; Derungs, Adrian; Exadaktylos, Aristomenis; Krähenbühl, Stephan; Liakoni, Evangelia (2021). Retrospective analysis of adverse drug reactions leading to short-term emergency hospital readmission. Swiss medical weekly, 151, w20400. EMH Media 10.4414/smw.2021.20400

Blaser, Lea S; Duthaler, Urs; Bouitbir, Jamal; Leuppi-Taegtmeyer, Anne B; Liakoni, Evangelia; Dolf, Reto; Mayr, Michael; Drewe, Jürgen; Krähenbühl, Stephan; Haschke, Manuel (2021). Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study. Frontiers in Pharmacology, 12(620635), p. 620635. Frontiers 10.3389/fphar.2021.620635


Cismaru, Anca Liliana; Rudin, Deborah; Ibañez, Luisa; Liakoni, Evangelia; Bonadies, Nicolas; Kreutz, Reinhold; Carvajal, Alfonso; Lucena, Maria Isabel; Martin, Javier; Sancho Ponce, Esther; Molokhia, Mariam; Eriksson, Niclas; EuDAC, Collaborators; Krähenbühl, Stephan; Largiadèr, Carlo R.; Haschke, Manuel Martin; Hallberg, Pär; Wadelius, Mia; Amstutz, Ursula (2020). Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations. Genes, 11(11) MDPI, Molecular Diversity Preservation International 10.3390/genes11111275

Stojkov, Kristina; Silzle, Tobias; Stussi, Georg; Schwappach, David; Bernhard, Juerg; Bowen, David; Čermák, Jaroslav; Dinmohamed, Avinash G; Eeltink, Corien; Eggmann, Sabrina; Fenaux, Pierre; Germing, Ulrich; Haschke, Manuel; Hellstrom-Lindberg, Eva; Heger, Monika; van de Loosdrecht, Arjan A; Passweg, Jakob; Pfeilstöcker, Michael; Platzbecker, Uwe; Malcovati, Luca; ... (2020). Guideline-based indicators for adult patients with myelodysplastic syndromes. Blood advances, 4(16), pp. 4029-4044. American Society of Hematology 10.1182/bloodadvances.2020002314

Boschung-Pasquier, Léna; Atkinson, Andrew; Kastner, Leonie Kassandra; Banholzer, Sarah; Haschke, Manuel; Buetti, Niccolò; Furrer, Dominique I; Hauser, Christoph; Jent, Philipp; Que, Yok-Ai; Furrer, Hansjakob; Babouee Flury, Baharak (2020). Cefepime neurotoxicity: thresholds and risk factors. A Retrospective Cohort study. Clinical microbiology and infection, 26(3), pp. 333-339. Elsevier 10.1016/j.cmi.2019.06.028

Suenderhauf, Claudia; Berger, Benjamin; Puchkov, Maxim; Schmid, Yasmin; Müller, Sabine; Huwyler, Jörg; Haschke, Manuel; Krähenbühl, Stephan; Duthaler, Urs (2020). Pharmacokinetics and phenotyping properties of the Basel phenotyping cocktail combination capsule in healthy male adults. British journal of clinical pharmacology, 86(2), pp. 352-361. Wiley-Blackwell 10.1111/bcp.14157

Bachmann, Fabio; Blaser, Lea; Haschke, Manuel Martin; Krähenbühl, Stephan; Duthaler, Urs (2020). Development and validation of an LC-MS/MS method for the bioanalysis of the major metamizole metabolites in human plasma. Bioanalysis, 12(3), pp. 175-189. Future Science 10.4155/bio-2019-0251

Cismaru, Anca Liliana; Grimm, Livia; Rudin, Deborah; Ibañez, Luisa; Liakoni, Evangelia; Bonadies, Nicolas; Kreutz, Reinhold; Hallberg, Pär; Wadelius, Mia; Haschke, Manuel; Largiadèr, Carlo R.; Amstutz, Ursula (2020). High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis. Frontiers in genetics, 11(951), p. 951. Frontiers Media SA 10.3389/fgene.2020.00951


Liakoni, Evangelia; Berger, Flavia; Klukowska-Rötzler, Jolanta; Kupferschmidt, Hugo; Haschke, Manuel; Exadaktylos, Aristomenis (2019). Characteristics of emergency department presentations requiring consultation of the national Poisons Information Centre. Swiss medical weekly, 149, w20164. EMH Media 10.4414/smw.2019.20164

Ziesenitz, Victoria C; Rodieux, Frédérique; Atkinson, Andrew; Borter, Carole; Bielicki, Julia A; Haschke, Manuel; Duthaler, Urs; Bachmann, Fabio; Erb, Thomas O; Gürtler, Nicolas; Holland-Cunz, Stefan; van den Anker, Johannes N; Gotta, Verena; Pfister, Marc (2019). Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study. European journal of clinical pharmacology, 75(11), pp. 1491-1502. Springer 10.1007/s00228-019-02720-2

Rudin, Deborah; Spoendlin, Julia; Cismaru, Anca L.; Liakoni, Evangelia; Bonadies, Nicolas; Amstutz, Ursula; Meier, Christoph R; Krähenbühl, Stephan; Haschke, Manuel (2019). Metamizole-associated neutropenia: Comparison of patients with neutropenia and metamizole-tolerant patients. European journal of internal medicine, 68, pp. 36-43. Elsevier 10.1016/j.ejim.2019.07.029

Scholz, Irene; Schmid, Yasmin; Exadaktylos, Aristomenis; Haschke, Manuel Martin; Liechti, Matthias E; Liakoni, Evangelia (2019). Emergency department presentations related to abuse of prescription and over-the-counter drugs in Switzerland: time trends, sex and age distribution. Swiss medical weekly, 149(w20056), w20056. EMH Media 10.4414/smw.2019.20056

Rudin, Deborah; Lanzilotto, Angelo; Bachmann, Fabio; Housecroft, Catherine E; Constable, Edwin C; Drewe, Jürgen; Haschke, Manuel Martin; Krähenbühl, Stephan (2019). Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells. Biochemical pharmacology, 163, pp. 345-356. Elsevier 10.1016/j.bcp.2019.01.011

Leuppi-Taegtmeyer, Anne; Duthaler, Urs; Hammann, Felix; Schmid, Yasmin; Dickenmann, Michael; Amico, Patricia; Jehle, Andreas W; Kalbermatter, Stefan; Lenherr, Christoph; Meyer Zu Schwabedissen, Henriette E; Haschke, Manuel Martin; Liechti, Matthias E; Krähenbühl, Stephan (2019). Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions. Nephrology, dialysis, transplantation, 34(4), pp. 692-702. Oxford University Press 10.1093/ndt/gfy285

Hoemme, Alexander; Barth, Holger; Haschke, Manuel Martin; Krähenbühl, Stephan; Strasser, Florian; Lehner, Claudia; von Kameke, Alexander; Wälti, Thomas; Thürlimann, Beat; Früh, Martin; Driessen, Christoph; Joerger, Markus (2019). Prognostic impact of polypharmacy and drug interactions in patients with advanced cancer. Cancer chemotherapy and pharmacology, 83(4), pp. 763-774. Springer 10.1007/s00280-019-03783-9

Piotrowska, Natalia; Klukowska-Rötzler, Jolanta; Lehmann, Beat; Krummrey, Gert; Haschke, Manuel; Exadaktylos, Aristomenis K.; Liakoni, Evangelia (2019). Presentations Related to Acute Paracetamol Intoxication in an Urban Emergency Department in Switzerland. Emergency medicine international, 2019, pp. 1-7. Hindawi Publishing Corporation 10.1155/2019/3130843


Bohlender, Jürgen; Nussberger, Jürg; Leuenberger, Samuel; Haschke, Manuel Martin (2018). Resistente Hypertonie. Swiss medical forum, 18(50), pp. 1059-1065. EMH Schweizerischer Ärzteverlag AG 10.4414/smf.2018.03451

Sandbaumhüter, Friederike Andrea; Haschke, Manuel Martin; Vogt, Bruno; Bohlender, Jürgen (2018). Medication adherence during laboratory workup for primary aldosteronism: pilot study. Patient preference and adherence, 12, pp. 2449-2455. Dove Medical Press 10.2147/PPA.S179488

Duthaler, Urs; Berger, Benjamin; Erb, Stefan; Battegay, Manuel; Letang, Emili; Gaugler, Stefan; Natamatungiro, Alex; Mnzava, Dorcas; Donzelli, Massimiliano; Krähenbühl, Stephan; Haschke, Manuel Martin (2018). Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions. The journal of antimicrobial chemotherapy, 73(10), pp. 2729-2737. Oxford University Press 10.1093/jac/dky254

Bachmann, Fabio; Duthaler, Urs; Rudin, Deborah; Krähenbühl, Stephan; Haschke, Manuel Martin (2018). N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole. European journal of pharmaceutical sciences, 120, pp. 172-180. Elsevier 10.1016/j.ejps.2018.05.003

Sandbaumhüter, Friederike Andrea; Haschke, Manuel Martin; Vogt, Bruno; Bohlender, Jürgen (2018). Indexed plasma drug concentrations for drug adherence screening in hypertensive patients. Annales de cardiologie et d'angéiologie, 67(3), pp. 119-126. Elsevier Masson 10.1016/j.ancard.2018.04.020

Berger, Benjamin; Bachmann, Fabio; Duthaler, Urs; Krähenbühl, Stephan; Haschke, Manuel Martin (2018). Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug. Frontiers in Pharmacology, 9(774), p. 774. Frontiers 10.3389/fphar.2018.00774

Hübner, Simona T; Bertoli, Raffaela; Rätz Bravo, Alexandra E; Schaueblin, Martina; Haschke, M.; Scherer, Kathrin; Ceschi, Alessandro; Leuppi-Taegtmeyer, Anne B (2018). C-Reactive Protein and Procalcitonin in Case Reports of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome. International archives of allergy and immunology, 176(1), pp. 44-54. Karger 10.1159/000487670


Freiermuth, David; Mets, Berend; Bolliger, Daniel; Reuthebuch, Oliver; Doebele, Thomas; Scholz, Markus; Gregor, Michael; Haschke, Manuel Martin; Seeberger, Manfred; Fassl, Jens (2017). Sevoflurane and Isoflurane-Pharmacokinetics, Hemodynamic Stability and Cardio-protective Effects During Cardiopulmonary Bypass. Journal of cardiothoracic and vascular anesthesia, 31(6), e85-e86. Elsevier 10.1053/j.jvca.2016.10.010

Erb, S; Letang, E; Glass, T R; Natamatungiro, A; Mnzava, D; Mapesi, H; Haschke, Manuel Martin; Duthaler, U; Berger, B; Muri, L; Bader, J; Marzolini, C; Elzi, L; Klimkait, T; Langewitz, W; Battegay, M (2017). Health care provider communication training in rural Tanzania empowers HIV-infected patients on antiretroviral therapy to discuss adherence problems. HIV medicine, 18(9), pp. 623-634. Blackwell Science 10.1111/hiv.12499

Parra-Guillen, Zinnia P; Berger, Peter B; Haschke, Manuel Martin; Donzelli, Massimiliano; Winogradova, Daria; Pfister, Bogumila; Früh, Martin; Gillessen, Silke; Krähenbühl, Stephan; Kloft, Charlotte; Joerger, Markus (2017). Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-small-Cell Lung Cancer Receiving Erlotinib Treatment. Basic & clinical pharmacology & toxicology, 121(4), pp. 309-315. Wiley-Blackwell 10.1111/bcpt.12801

Duthaler, U; Berger, B; Erb, S; Battegay, M; Letang, E; Gaugler, S; Krähenbühl, S; Haschke, Manuel Martin (2017). Automated high throughput analysis of antiretroviral drugs in dried blood spots. Journal of mass spectrometry, 52(8), pp. 534-542. Wiley 10.1002/jms.3952

Blaser, Lea; Hassna, Hala; Hofmann, Sarah; Holbro, Andreas; Haschke, Manuel Martin; Rätz Bravo, Alexandra; Zeller, Andreas; Krähenbühl, Stephan; Taegtmeyer, Anne (2017). Leucopenia associated with metamizole: a case-control study. Swiss medical weekly, 147, w14438. EMH Schweizerischer Ärzteverlag 10.4414/smw.2017.14438

Krisai, Philipp; Haschke, Manuel Martin; Buser, Peter T; Mueller, Christian (2017). Ticagrelor induced systemic inflammatory response syndrome. BMC cardiovascular disorders, 17(1), p. 14. BioMed Central 10.1186/s12872-016-0443-8

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