Spectral-Domain Optical Coherence Tomography Associations of Neovascular Conversion in Age-Related Macular Degeneration

Yu, Siqing; Wolf, Sebastian; Munk, Marion R.; Zinkernagel, Martin; Ebneter, Andreas (2018). Spectral-Domain Optical Coherence Tomography Associations of Neovascular Conversion in Age-Related Macular Degeneration. Journal of vitreoretinal diseases, 2(2), pp. 69-78. Sage 10.1177/2474126418756405

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Purpose: To identify spectral-domain optical coherence tomography (SD-OCT) features associated with exudative conversion
in fellow eyes of patients treated for neovascular age-related macular degeneration (nAMD) in their first eye. Methods: Retrospective
observational study. Spectral-domain optical coherence tomography images of converting fellow eyes (study eyes)
from 83 patients with nAMD were compared to fellow eyes of age- and sex-matched patients with nAMD who did not convert
(control eyes). Parameters related to drusen, pigment epithelium detachment, hyperreflective foci (HRF), retinal pigment epithelium
atrophy, small cystic cavities, and vitreoretinal interface were graded. Longitudinal analysis in study eyes and crosssectional
comparison with control eyes at the last 3 semiannual visits before nAMD conversion were performed. Results: For
most biomarkers, the prevalence in study eyes increased and imaging findings worsened more than in control eyes. Drusen size
and reticular pseudodrusen presence were significantly greater in converting eyes at all 3 time points. Outer retinal small cystic
cavities were significantly more common in study eyes shortly before conversion. Binary logistic regression revealed that biggest
drusen width was significantly associated with nAMD at all 3 time points (odds ratio [OR] > 1.010; P < .001). The presence of soft
drusen was strongly associated with nAMD 18 months before conversion (OR: 7.034; P ¼ .040). Clustering HRF in the inner
retina were significantly associated with nAMD both 12 (OR: 1.324; P ¼ .049) and 6 months (OR: 2.161; P ¼ .035) before
conversion. Conclusions: Emergence of HRF in fellow eyes, particularly in the inner retina, are sensitive SD-OCT features
indicating conversion to exudative disease in patients treated unilaterally for nAMD.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Augenklinik > Forschungsgruppe Augenheilkunde

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Yu, Siqing; Wolf, Sebastian; Zinkernagel, Martin and Ebneter, Andreas


600 Technology > 610 Medicine & health








Andreas Ebneter

Date Deposited:

01 Mar 2018 10:13

Last Modified:

22 Aug 2018 10:20

Publisher DOI:




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