Cigarette smoking and cerebral blood flow in a cohort of middle-aged adults.

Elbejjani, Martine; Auer, Reto; Dolui, Sudipto; Jacobs, David R; Haight, Thaddeus; Goff, David C; Detre, John A; Davatzikos, Christos; Bryan, R Nick; Launer, Lenore J (2019). Cigarette smoking and cerebral blood flow in a cohort of middle-aged adults. Journal of cerebral blood flow and metabolism, 39(7), pp. 1247-1257. Nature Publishing Group 10.1177/0271678X18754973

	Text Elbejjani JCerebBloodFlowMetab 2018.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (164kB)
	Text Elbejjani JCerebBloodFlowMetab 2018_supplmat.pdf - Supplemental Material Restricted to registered users only Available under License Publisher holds Copyright. Download (410kB)

Cigarette smoking is often associated with dementia. This association is thought to be mediated by hypoperfusion; however, how smoking behavior relates to cerebral blood flow (CBF) remains unclear. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort (mean age = 50; n = 522), we examined the association between smoking behavior (status, cumulative pack-years, age at smoking initiation, and years since cessation) and CBF (arterial spin labeling) in brain lobes and regions linked to dementia. We used adjusted linear regression models and tested whether associations differed between current and former-smokers. Compared to never-smokers, former-smokers had lower CBF in the parietal and occipital lobes, cuneus, precuneus, putamen, and insula; in contrast, current-smokers did not have lower CBF. The relationship between pack-years and CBF was different between current and former-smokers ( p for interaction < 0.05): Among current-smokers, higher pack-years were associated with higher occipital, temporal, cuneus, putamen, insula, hippocampus, and caudate CBF; former-smokers had lower caudate CBF with increasing pack-years. Results show links between smoking and CBF at middle-age in regions implicated in cognitive and compulsive/addictive processes. Differences between current and former smoking suggest that distinct pathological and/or compensatory mechanisms may be involved depending on the timing and history of smoking exposure.

Interest & Impact

Downloads

6 since deposited on 06 Feb 2018
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item