Blood perfusion in left inferior and middle frontal gyrus predicts communication skills in schizophrenia.

Cantisani, Andrea; Stegmayer, Katharina; Federspiel, Andrea; Bohlhalter, Stephan; Wiest, Roland; Walther, Sebastian (2018). Blood perfusion in left inferior and middle frontal gyrus predicts communication skills in schizophrenia. Psychiatry research: Neuroimaging, 274, pp. 7-10. Elsevier 10.1016/j.pscychresns.2018.02.002

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Schizophrenia is one of the most debilitating mental disorders, severely affecting patients' community functioning. Functional capacity (FC) describes the skills necessary for successful functional outcome (FO), such as financial knowledge or communication skills. We investigated whether resting-state cerebral blood flow (rCBF) measured at baseline with arterial spin labeling (ASL) would predict FC or FO at a 6-months follow-up in 27 schizophrenia patients. A negative linear association was noted between FC and rCBF in the left inferior and middle frontal gyrus, areas involved in language processing, suggesting a potential relationship between cerebral perfusion and prospective FC in schizophrenia.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Cantisani, Andrea; Stegmayer, Katharina; Federspiel, Andrea; Wiest, Roland and Walther, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0925-4927

Publisher:

Elsevier

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

23 Apr 2018 09:16

Last Modified:

23 Apr 2018 09:16

Publisher DOI:

10.1016/j.pscychresns.2018.02.002

PubMed ID:

29456122

Uncontrolled Keywords:

Arterial spin labeling Functional capacity Functional outcome Resting-state cerebral blood flow Schizophrenia

BORIS DOI:

10.7892/boris.112075

URI:

https://boris.unibe.ch/id/eprint/112075

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