Reigel, F.; Burkhardt, F.; Schilt, U. (1985). Cross-reactions of immunoglobulin M and G antibodies with enterovirus-specific viral structural proteins. Journal of hygiene, 95(2), pp. 469-481. Cambridge University Press 10.1017/S0022172400062896
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We analysed the reactivity of enterovirus-specific human IgM and IgG antibodies with the structural proteins of different enteroviruses by the immunoblot technique. In general, all immunoglobulin G antibodies of the tested sera reacted with capsid polypeptide VP 1 of the viruses tested (echoviruses 9 and 11, coxsackievirus B3 and poliovirus 2). In contrast, enterovirus specific immunoglobulin M antibodies of adults reacted with capsid polypeptides VP 1, VP 2, and/or VP 3 of the viruses mentioned above. The reactions with VP 2 and/or VP 3 were often stronger than with VP 1. IgM antibodies from sera of newborns infected by echovirus 11 reacted with VP 1 and VP 2/3 of echovirus 11 and also with VP 2 and VP 3 of poliovirus 2. Preabsorption experiments indicate that cross-reactive IgG antibodies react with epitopes of VP 1 not present on the surface of intact virus particles. The results from the immunoblot technique were compared to data from microneutralization tests and M-antibody capture radioimmunoassays.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
ISSN: |
0022-1724 |
Publisher: |
Cambridge University Press |
Language: |
English |
Submitter: |
Marceline Brodmann |
Date Deposited: |
30 Jul 2020 16:46 |
Last Modified: |
30 Jul 2020 16:46 |
Publisher DOI: |
10.1017/S0022172400062896 |
BORIS DOI: |
10.7892/boris.115090 |
URI: |
https://boris.unibe.ch/id/eprint/115090 |
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