Analgesic action of i.v. morphine-6-glucuronide in healthy volunteers.

Buetler, T. M.; Wilder-Smith, O. H. G.; Wilder-Smith, C. H.; Aebi, S.; Cerny, T.; Brenneisen, R. (2000). Analgesic action of i.v. morphine-6-glucuronide in healthy volunteers. British journal of anaesthesia, 84(1), pp. 97-99. Oxford University Press 10.1093/oxfordjournals.bja.a013391

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The pharmacodynamics of morphine-6-glucuronide (M-6-G) i.v. were assessed in 12 healthy male volunteers in an open study. After a single bolus dose of M-6-G 5 mg i.v., we measured antinociceptive effects, using electrical and cold pain tests, and plasma concentrations of M-6-G, morphine-3-glucuronide (M-3-G) and morphine. Pain intensities during electrical stimulation (at 30, 60 and 90 min after injection) and ice water immersion (at 60 min) decreased significantly (P < 0.005) compared with baseline. Mean plasma peak concentrations of M-6-G were 139.3 (SD 38.9) ng ml-1, measured at 15 min. Our data demonstrate that M-6-G has significant analgesic activity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Aebi, Stefan and Brenneisen, Rudolf Max

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0007-0912

Publisher:

Oxford University Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

30 Sep 2020 16:00

Last Modified:

30 Sep 2020 16:00

Publisher DOI:

10.1093/oxfordjournals.bja.a013391

BORIS DOI:

10.7892/boris.115381

URI:

https://boris.unibe.ch/id/eprint/115381

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