Buetler, T. M.; Wilder-Smith, O. H. G.; Wilder-Smith, C. H.; Aebi, S.; Cerny, T.; Brenneisen, R. (2000). Analgesic action of i.v. morphine-6-glucuronide in healthy volunteers. British journal of anaesthesia, 84(1), pp. 97-99. Oxford University Press 10.1093/oxfordjournals.bja.a013391
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The pharmacodynamics of morphine-6-glucuronide (M-6-G) i.v. were assessed in 12 healthy male volunteers in an open study. After a single bolus dose of M-6-G 5 mg i.v., we measured antinociceptive effects, using electrical and cold pain tests, and plasma concentrations of M-6-G, morphine-3-glucuronide (M-3-G) and morphine. Pain intensities during electrical stimulation (at 30, 60 and 90 min after injection) and ice water immersion (at 60 min) decreased significantly (P < 0.005) compared with baseline. Mean plasma peak concentrations of M-6-G were 139.3 (SD 38.9) ng ml-1, measured at 15 min. Our data demonstrate that M-6-G has significant analgesic activity.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Aebi, Stefan, Brenneisen, Rudolf Max |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0007-0912 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Marceline Brodmann |
Date Deposited: |
30 Sep 2020 16:00 |
Last Modified: |
05 Dec 2022 15:13 |
Publisher DOI: |
10.1093/oxfordjournals.bja.a013391 |
BORIS DOI: |
10.7892/boris.115381 |
URI: |
https://boris.unibe.ch/id/eprint/115381 |
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