Role of thromboxane and leukotriene B4 in patients with acute respiratory distress syndrome after oesophagectomy.

Schilling, M. K.; Gassmann, N.; Sigurdsson, G. H.; Regli, B.; Stoupis, C.; Furrer, M.; Signer, C.; Redaelli, C.; Büchler, M. W. (1998). Role of thromboxane and leukotriene B4 in patients with acute respiratory distress syndrome after oesophagectomy. British journal of anaesthesia, 80(1), pp. 36-40. Oxford University Press 10.1093/bja/80.1.36

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We have studied prospectively the clinical course and serum concentrations of thromboxane B2 (TxB2) and leukotriene B4 (LTB4) in patients developing adult respiratory distress syndrome (ARDS) after oesophagectomy. The clinical course was assessed according to a validated ARDS score, and intra- and postoperative measurements of TxB2 and LTB4 in pre- and post-pulmonary blood were performed in 18 patients undergoing oesophagectomy for oesophageal carcinoma and 11 control patients undergoing thoracotomy and pulmonary resection. Six of 18 patients undergoing oesophagectomy, but no control patient, developed ARDS. The ARDS score was highest on day 8 after operation. Only patients with ARDS had a significant postoperative increase in post-pulmonary, but not pre-pulmonary, TxB2 concentrations (P < 0.05 vs patients without ARDS). This study provides evidence that TxA2, originating from the lungs, was associated with the development of ARDS after oesophageal resection. In view of the high incidence of ARDS after oesophagectomy (10-30%), prophylactic treatment of patients undergoing oesophageal resection with clinically applicable thromboxane synthetase inhibitors may be warranted.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Regli, Bruno; Stoupis, Christoforos; Redaelli, Claudio Antonio and Büchler, Markus Wolfgang

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0007-0912

Publisher:

Oxford University Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

30 Sep 2020 16:35

Last Modified:

30 Sep 2020 16:35

Publisher DOI:

10.1093/bja/80.1.36

BORIS DOI:

10.7892/boris.115861

URI:

https://boris.unibe.ch/id/eprint/115861

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