Comparison of the analgesic potency of xenon and nitrous oxide in humans evaluated by experimental pain.

Petersen-Felix, S.; Luginbühl, M; Schnider, T. W.; Curatolo, M.; Arendt-Nielsen, L.; Zbinden, A. M. (1998). Comparison of the analgesic potency of xenon and nitrous oxide in humans evaluated by experimental pain. British journal of anaesthesia, 81(5), pp. 742-747. Oxford University Press 10.1093/bja/81.5.742

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We have compared the analgesic potency of MAC-equivalent concentrations of xenon (10, 20, 30 and 40%) and nitrous oxide (15, 30, 45 and 60%) in humans using a multimodal experimental pain testing and assessment technique. We tested 12 healthy volunteers in a randomized, single-blind, crossover study. The following experimental pain tests were used: nociceptive reflex to repeated stimuli; pain tolerance to maximal effort tourniquet ischaemia; electrical stimulation; mechanical pressure; and cold. Reaction time was also measured. Xenon and nitrous oxide produced analgesia to ischaemic, electrical and mechanical stimulation, but not to cold pain. There was no difference in MAC-equivalent concentrations of xenon and nitrous oxide. Both increased reaction time in a similar manner. Xenon and nitrous oxide evoked nausea and vomiting in a large number of volunteers.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Petersen, Steen; Luginbühl, Martin; Curatolo, Michele and Zbinden, Alex Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0007-0912

Publisher:

Oxford University Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

30 Sep 2020 18:33

Last Modified:

30 Sep 2020 18:33

Publisher DOI:

10.1093/bja/81.5.742

BORIS DOI:

10.7892/boris.115864

URI:

https://boris.unibe.ch/id/eprint/115864

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