Petersen-Felix, S.; Luginbühl, M; Schnider, T. W.; Curatolo, M.; Arendt-Nielsen, L.; Zbinden, A. M. (1998). Comparison of the analgesic potency of xenon and nitrous oxide in humans evaluated by experimental pain. British journal of anaesthesia, 81(5), pp. 742-747. Oxford University Press 10.1093/bja/81.5.742
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We have compared the analgesic potency of MAC-equivalent concentrations of xenon (10, 20, 30 and 40%) and nitrous oxide (15, 30, 45 and 60%) in humans using a multimodal experimental pain testing and assessment technique. We tested 12 healthy volunteers in a randomized, single-blind, crossover study. The following experimental pain tests were used: nociceptive reflex to repeated stimuli; pain tolerance to maximal effort tourniquet ischaemia; electrical stimulation; mechanical pressure; and cold. Reaction time was also measured. Xenon and nitrous oxide produced analgesia to ischaemic, electrical and mechanical stimulation, but not to cold pain. There was no difference in MAC-equivalent concentrations of xenon and nitrous oxide. Both increased reaction time in a similar manner. Xenon and nitrous oxide evoked nausea and vomiting in a large number of volunteers.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy |
UniBE Contributor: |
Petersen, Steen, Luginbühl, Martin, Curatolo, Michele, Zbinden, Alex Martin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0007-0912 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Marceline Brodmann |
Date Deposited: |
30 Sep 2020 18:33 |
Last Modified: |
05 Dec 2022 15:13 |
Publisher DOI: |
10.1093/bja/81.5.742 |
BORIS DOI: |
10.7892/boris.115864 |
URI: |
https://boris.unibe.ch/id/eprint/115864 |
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