Towards a Synthetic Mitochondrion.

Biner, Olivier Felix; Schick, Thomas; Ganguin, Aymar Abel; von Ballmoos, Christoph (2018). Towards a Synthetic Mitochondrion. CHIMIA, 72(5), pp. 291-296. Schweizerische Chemische Gesellschaft 10.2533/chimia.2018.291

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Our group at the University of Bern uses biochemical and biophysical techniques to unravel details of the molecular mechanism of membrane proteins. Of special interest are the large multi-subunit complexes of the universally conserved respiratory chain and the ATP synthase that are found in mitochondria and aerobic bacteria. In a bottom-up approach using purified membrane proteins and synthetic lipids, we aim to mimic the basic processes of oxidative phosphorylation. We further develop methodologies to increase the complexity of such artificial systems, paving the way for a synthetic mitochondrion. In this minireview, we summarize recent efforts of our groups and others towards a synthetic respiratory chain.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Biner, Olivier Felix; Schick, Thomas and von Ballmoos, Christoph

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0009-4293

Publisher:

Schweizerische Chemische Gesellschaft

Language:

English

Submitter:

Olivier Felix Biner

Date Deposited:

04 Jun 2018 14:33

Last Modified:

04 Jun 2018 14:33

Publisher DOI:

10.2533/chimia.2018.291

PubMed ID:

29789065

BORIS DOI:

10.7892/boris.116897

URI:

https://boris.unibe.ch/id/eprint/116897

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