O12.5 Factors associated with antimicrobial resistant gonorrhoea infections in men who have sex with men: case-control study

Low, Nicola; B, Bertisch; Hauser, C; M, Kluschke; Kasraian, S; Egli-Gany, Dianne; Smid, J; M, Unemo; Endimiani, A; Donà, V; Furrer, H (2017). O12.5 Factors associated with antimicrobial resistant gonorrhoea infections in men who have sex with men: case-control study. Sexually transmitted infections, 93(Suppl 2), A28.2-A28. BMJ Publishing Group 10.1136/sextrans-2017-053264.70

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Introduction Strategies to identify antimicrobial resistance (AMR) and improve antibiotic stewardship to control the spread of AMR in Neisseria gonorrhoeae (NG) are urgently needed. As part of a project to develop a point-of-care (POC) test for AMR in NG, we investigated factors that could help identify infections due to antibiotic resistant NG. Methods We enrolled men who have sex with men (MSM) at sexual health centres in Zurich and Bern, Switzerland, from May 2015 to June 2016. All had samples taken for NG detection from urethra, rectum and pharynx. In culture positive specimens we obtained minimum inhibitory concentrations (MICs) using Etest for ciprofloxacin, ceftriaxone, cefixime and spectinomycin (EUCAST AMR breakpoints) and azithromycin (EuroGASP, >2 mg/L). We collected clinical data and patients completed an online questionnaire. We compared cases (positive NG culture and AMR) with controls (NG and no AMR) with odds ratios (OR) and 95% confidence intervals (CI). We used multivariable logistic regression in MSM with complete data for all included variables. Results Of 230 MSM enrolled, 117 had a positive NG culture. There were 46 (39%) cases with resistant NG (ciprofloxacin, n=45, azithromycin, n=1) and 71 controls. Clinical findings did not differ between cases and controls. Cases were more likely than controls to have had sex outside Switzerland in the previous 3 months (OR 2.2, 95% CI 1.0–4.7, p=0.05), to have received oral sex (OR 5.6, 95% CI 0.7–46.8, p=0.08) and to have concurrent partnerships (OR 2.2, 95% CI 0.8–6.5, p=0.11). In multivariable analysis (39 cases, 54 controls), the association with sex abroad remained (OR 2.0, 95% CI 0.9–4.8, p=0.10), controlling for

Item Type:

Conference or Workshop Item (Abstract)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Low, Nicola; Hauser, Christoph Victor; Kasraian Fard, Sara; Egli, Dianne; Smid, Joost Hubert; Endimiani, Andrea; Donà, Valentina and Furrer, Hansjakob

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1368-4973

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Tanya Karrer

Date Deposited:

08 Jun 2018 01:32

Last Modified:

11 Jun 2018 15:12

Publisher DOI:

10.1136/sextrans-2017-053264.70

BORIS DOI:

10.7892/boris.116928

URI:

https://boris.unibe.ch/id/eprint/116928

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