Presumptive BSE cases with an aberrant prion protein phenotype in Switzerland, 2011: Lack of prion disease in experimentally inoculated cattle and bovine prion protein transgenic mice.

Serra, F; Dudas, S; Torres, J M; Anderson, R; Oevermann, Anna; Espinosa, J C; Czub, S; Seuberlich, Torsten (2018). Presumptive BSE cases with an aberrant prion protein phenotype in Switzerland, 2011: Lack of prion disease in experimentally inoculated cattle and bovine prion protein transgenic mice. Transboundary and emerging diseases, 65(5), pp. 1348-1356. Wiley 10.1111/tbed.12884

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Bovine spongiform encephalopathy (BSE) is caused by different prion strains that are discriminated by the molecular characteristics of the pathological prion protein. In 2011, Switzerland reported two presumptive cases of BSE in cattle with a prion protein phenotype different from previously described strains, and it was unclear whether these findings were related to a transmissible disease and have implications on animal and public health. In this study, brain tissues of these cases were inoculated into transgenic mice expressing the bovine prion protein (BoPrP-Tg110) and into cattle. Clinical and pathological investigations as well as molecular testing did not provide evidence for the presence of BSE in the Swiss cases after two passages in BoPrP-Tg110 mice and a challenge period of 3.5 years in cattle. This lack of disease transmission suggests that the Swiss 2011 cases were not affected by a prion disease and were unrelated to the feed-born BSE epidemic.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Research Foci > NeuroCenter

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Oevermann, Anna and Seuberlich, Torsten

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1865-1682

Publisher:

Wiley

Language:

English

Submitter:

Anna Oevermann

Date Deposited:

06 Jun 2018 16:50

Last Modified:

23 Oct 2019 22:45

Publisher DOI:

10.1111/tbed.12884

PubMed ID:

29675959

Uncontrolled Keywords:

atypical bovine spongiform encephalopathy cattle prion transmissible spongiform encephalopathies zoonosis

BORIS DOI:

10.7892/boris.117019

URI:

https://boris.unibe.ch/id/eprint/117019

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