Coupling 1D modifications and 3D nuclear organization: data, models and function.

Jost, Daniel; Vaillant, Cédric; Meister, Peter (2017). Coupling 1D modifications and 3D nuclear organization: data, models and function. Current opinion in cell biology, 44, pp. 20-27. Elsevier 10.1016/j.ceb.2016.12.001

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Over the past decade, advances in molecular methods have strikingly improved the resolution at which nuclear genome folding can be analyzed. This revealed a wealth of conserved features organizing the one dimensional DNA molecule into tridimensional nuclear domains. In this review, we briefly summarize the main findings and highlight how models based on polymer physics shed light on the principles underlying the formation of these domains. Finally, we discuss the mechanistic similarities allowing self-organization of these structures and the functional importance of these in the maintenance of transcriptional programs.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Meister, Pierre

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0955-0674

Publisher:

Elsevier

Funders:

[42] Schweizerischer Nationalfonds
[UNSPECIFIED] FSRMM

Language:

English

Submitter:

Pierre Meister

Date Deposited:

27 Jul 2020 13:39

Last Modified:

27 Jul 2020 13:39

Publisher DOI:

10.1016/j.ceb.2016.12.001

PubMed ID:

28040646

BORIS DOI:

10.7892/boris.117297

URI:

https://boris.unibe.ch/id/eprint/117297

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