Jost, Daniel; Vaillant, Cédric; Meister, Peter (2017). Coupling 1D modifications and 3D nuclear organization: data, models and function. Current opinion in cell biology, 44, pp. 20-27. Elsevier 10.1016/j.ceb.2016.12.001
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Over the past decade, advances in molecular methods have strikingly improved the resolution at which nuclear genome folding can be analyzed. This revealed a wealth of conserved features organizing the one dimensional DNA molecule into tridimensional nuclear domains. In this review, we briefly summarize the main findings and highlight how models based on polymer physics shed light on the principles underlying the formation of these domains. Finally, we discuss the mechanistic similarities allowing self-organization of these structures and the functional importance of these in the maintenance of transcriptional programs.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Cell Biology |
UniBE Contributor: |
Meister, Pierre |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
0955-0674 |
Publisher: |
Elsevier |
Funders: |
[42] Schweizerischer Nationalfonds ; [UNSPECIFIED] FSRMM |
Language: |
English |
Submitter: |
Pierre Meister |
Date Deposited: |
27 Jul 2020 13:39 |
Last Modified: |
05 Dec 2022 15:14 |
Publisher DOI: |
10.1016/j.ceb.2016.12.001 |
PubMed ID: |
28040646 |
BORIS DOI: |
10.7892/boris.117297 |
URI: |
https://boris.unibe.ch/id/eprint/117297 |
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