Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration.

Sánchez-Iranzo, Héctor; Galardi-Castilla, María; Minguillón, Carolina; Sanz Morejon, Andrés; González-Rosa, Juan Manuel; Felker, Anastasia; Ernst, Alexander Uwe Johann; Guzmán-Martínez, Gabriela; Mosimann, Christian; Mercader Huber, Nadia Isabel (2018). Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration. Nature communications, 9(1), p. 428. Nature Publishing Group 10.1038/s41467-017-02650-6

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During development, mesodermal progenitors from the first heart field (FHF) form a primitive cardiac tube, to which progenitors from the second heart field (SHF) are added. The contribution of FHF and SHF progenitors to the adult zebrafish heart has not been studied to date. Here we find, using genetic tbx5a lineage tracing tools, that the ventricular myocardium in the adult zebrafish is mainly derived from tbx5a cells, with a small contribution from tbx5a SHF progenitors. Notably, ablation of ventricular tbx5a-derived cardiomyocytes in the embryo is compensated by expansion of SHF-derived cells. In the adult, tbx5a expression is restricted to the trabeculae and excluded from the outer cortical layer. tbx5a-lineage tracing revealed that trabecular cardiomyocytes can switch their fate and differentiate into cortical myocardium during adult heart regeneration. We conclude that a high degree of cardiomyocyte cell fate plasticity contributes to efficient regeneration.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy
09 Interdisciplinary Units > Microscopy Imaging Center (MIC)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Sanz Morejon, Andrés; Ernst, Alexander Uwe Johann and Mercader Huber, Nadia Isabel

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2041-1723

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Nadia Isabel Mercader Huber

Date Deposited:

03 Jul 2018 07:32

Last Modified:

22 Oct 2019 20:52

Publisher DOI:

10.1038/s41467-017-02650-6

PubMed ID:

29382818

BORIS DOI:

10.7892/boris.118215

URI:

https://boris.unibe.ch/id/eprint/118215

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