Revised time scales of RNA virus evolution based on spatial information

Saxenhofer, Moritz; Weber de Melo, Vanessa; Ulrich, Rainer G.; Heckel, Gerald (2017). Revised time scales of RNA virus evolution based on spatial information. Proceedings of the Royal Society. Series B - biological sciences, 284(1860), p. 20170857. Royal Society of London 10.1098/rspb.2017.0857

[img] Text
20170857.full.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (3MB) | Request a copy

The time scales of pathogen evolution are of major concern in the context of public and veterinary health, epidemiology and evolutionary biology. Dating the emergence of a pathogen often relies on estimates of evolutionary rates derived from nucleotide sequence data. For many viruses, this has yielded estimates of evolutionary origins only a few hundred years in the past. Here we demonstrate through the incorporation of geographical information from virus sampling that evolutionary age estimates of two European hantaviruses are severely underestimated because of pervasive mutational saturation of nucleotide sequences. We detected very strong relationships between spatial distance and genetic divergence for both Puumala and Tula hantavirus—irrespective of whether nucleotide or derived amino acid sequences were analysed. Extrapolations from these relationships dated the emergence of these viruses most conservatively to at least 3700 and 2500 years ago, respectively. Our minimum estimates for the age of these hantaviruses are ten to a hundred times older than results from current non-spatial methods, and in much better accordance with the biogeography of these viruses and their respective hosts. Spatial information can thus provide valuable insights on the deeper time scales of pathogen evolution and improve our understanding of disease emergence.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE)

UniBE Contributor:

Saxenhofer, Moritz and Heckel, Gerald

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0962-8452

Publisher:

Royal Society of London

Language:

English

Submitter:

Susanne Holenstein

Date Deposited:

24 Jul 2018 07:48

Last Modified:

24 Oct 2019 04:12

Publisher DOI:

10.1098/rspb.2017.0857

BORIS DOI:

10.7892/boris.118917

URI:

https://boris.unibe.ch/id/eprint/118917

Actions (login required)

Edit item Edit item
Provide Feedback