Respiratory rate in infants with cystic fibrosis throughout the first year of life and association with lung clearance index measured shortly after birth.

Korten, Insa; Kieninger, Elisabeth; Yammine, Sophie; Cangiano, Giulia; Nyilas, Sylvia; Anagnostopoulou, Pinelopi; Singer, Florian; Kuehni, Claudia E; Regamey, Nicolas; Frey, Urs; Casaulta, Carmen; Spycher, Ben D; Latzin, Philipp; Study Group, SCILD; Study Group, BILD (2019). Respiratory rate in infants with cystic fibrosis throughout the first year of life and association with lung clearance index measured shortly after birth. Journal of cystic fibrosis, 18(1), pp. 118-126. Elsevier 10.1016/j.jcf.2018.07.002

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BACKGROUND Lung impairment in cystic fibrosis (CF) starts in infancy. However, tools to monitor early lung disease are limited. Respiratory rate (RR) as a key vital sign is easy to assess during sleep and is elevated during acute respiratory disease. Thus, elevated RR could indicate early lung impairment and potentially serve as a diagnostic tool in disease monitoring. METHODS In a prospective cohort of infants with CF diagnosed by newborn screening and healthy controls RR was measured and respiratory symptoms reported weekly throughout infancy. Infants performed a lung function measurement within the first weeks of life. RESULTS The analyses included 5656 measurements from 153 infants (43 with CF). RR declined from 43.2 (40.5)/min at 6 weeks of age to 28.3 (24.6)/min at 50 weeks in infants with CF (healthy controls). Infants with CF had consistently higher RR than controls (mean difference: 4.15/min; (95% CI 2.86-5.44); p < .001). In both study groups, RR was increased throughout the study period in infants with higher lung clearance indices (LCI) and during episodes of respiratory infections. CONCLUSIONS Infants with CF have a higher RR compared to healthy controls during the first year of life. The association with early LCI measurements, the current gold standard to assess physiology of peripheral airways persisted throughout the study period. This may indicate tracking of lung function by RR. It might thus be an early subtle sign of functional respiratory deficit. Further studies will show if RR can be used as a sensitive and promising marker to monitor early CF lung disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Korten, Insa Christina Severine; Kieninger, Elisabeth; Yammine, Sophie; Nyilas, Sylvia Meryl; Anagnostopoulou, Pinelopi; Singer, Florian; Kühni, Claudia; Regamey, Nicolas; Casaulta, Carmen; Spycher, Ben and Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1569-1993

Publisher:

Elsevier

Language:

English

Submitter:

Tanya Karrer

Date Deposited:

28 Aug 2018 12:52

Last Modified:

23 Jan 2019 01:31

Publisher DOI:

10.1016/j.jcf.2018.07.002

PubMed ID:

30060960

Uncontrolled Keywords:

Cystic fibrosis Infancy Infant lung function Lung clearance index Respiratory rate

BORIS DOI:

10.7892/boris.119335

URI:

https://boris.unibe.ch/id/eprint/119335

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