Irreversible electroporation in pancreatic cancer

Holzgang, Melanie Martina; Eigl, Benjamin; Erdem, Suna; Gloor, Beat; Worni, Mathias (2018). Irreversible electroporation in pancreatic cancer. In: Rodrigo, Luis (ed.) Advances in Pancreatic Cancer (pp. 97-114). IntechOpen 10.5772/intechopen.75737

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Pancreatic cancer is the deadliest of the gastrointestinal tract with 5-year survival rates of less than 5%. Given common asymptomatic early disease course, most patients (50%) present with an already metastatic disease, while only 20% can undergo potentially curative resection. The remaining 30% present with locally advanced disease, defined as extended vascular encasement, where the risk of surgical therapy often outweighs its benefits. Traditional thermal local ablative modalities (RFA, MWA, or cryotherapy) have the disadvantage that they are not applicable in proximity to vital vascular structures, which are abundant in the peripancreatic region. Irreversible electroporation (IRE) is an emerging non-thermal alternative that induces apoptosis of tumor cells by the delivery of short repetitive impulses of high-voltage electric current. Given its mostly non-thermal modality, IRE is not hampered by a heat-sink-effect and is applicable with little risk around vascular structures, bile and pancreatic ducts. Recent research suggests that local tumor destruction through IRE improves overall survival, progression-free survival and quality of life in patients with locally advanced pancreatic cancer.

Item Type:

Book Section (Book Chapter)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Holzgang, Melanie Martina; Eigl, Benjamin Peter; Erdem, Suna; Gloor, Beat and Worni, Mathias

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

ISBN:

978-1-78923-641-5

Publisher:

IntechOpen

Language:

English

Submitter:

Benjamin Peter Eigl

Date Deposited:

10 Sep 2018 10:51

Last Modified:

10 Jun 2020 15:25

Publisher DOI:

10.5772/intechopen.75737

BORIS DOI:

10.7892/boris.119902

URI:

https://boris.unibe.ch/id/eprint/119902

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