Hearing loss and quality of life in survivors of paediatric CNS tumours and other cancers [Brief Communication].

Weiss, Annette; Sommer, Grit; Schindera, Christina; Wengenroth, Laura; Karow, Axel; Diezi, Manuel; Michel, Gisela; Kuehni, Claudia E; Oncology Group (SPOG), Swiss Paediatric (2019). Hearing loss and quality of life in survivors of paediatric CNS tumours and other cancers [Brief Communication]. Quality of life research, 28(2), pp. 515-521. Springer 10.1007/s11136-018-2021-2

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PURPOSE Hearing loss, a complication of cancer treatment, may reduce health-related quality of life (HRQoL), especially in childhood cancer survivors of central nervous system (CNS) tumours who often have multiple late effects. We examined the effect of hearing loss on HRQoL in young survivors of CNS and other childhood cancers. METHODS Within the Swiss Childhood Cancer Survivor Study, we sent questionnaires about hearing loss and HRQoL (KIDSCREEN-27) to parents of survivors aged 8-15 years. We stratified the effect of hearing loss on HRQoL by cancer diagnosis, using multivariable logistic regression and adjusting for sociodemographic and clinical factors. RESULTS Hearing loss was associated with impaired physical well-being [unadjusted estimated differences - 4.6 (CI - 9.2, - 0.1); adjusted - 4.0 (CI - 7.6, - 0.3)] and peers and social support [unadjusted - 6.7 (CI - 13.0, - 0.3); adjusted - 5.0 (CI - 10.5, 0.9)] scores in survivors of CNS tumours (n = 123), but not in children diagnosed with other cancers (all p-values > 0.20, n = 577). CONCLUSION Clinicians should be alert to signs of reduced physical well-being and impaired relationships with peers. Especially survivors of CNS tumours may benefit most from strict audiological monitoring and timely intervention to mitigate secondary consequences of hearing loss on HRQoL.

Item Type:

Journal Article (Further Contribution)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Weiss, Annette Gerda; Sommer, Grit; Schindera, Christina; Karow, Axel and Kühni, Claudia


300 Social sciences, sociology & anthropology > 360 Social problems & social services
600 Technology > 610 Medicine & health








Tanya Karrer

Date Deposited:

24 Oct 2018 14:43

Last Modified:

10 Nov 2019 20:59

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Cancer treatment Childhood cancer Late effects Ototoxicity Swiss Childhood Cancer Registry Swiss Childhood Cancer Survivor Study





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