Alternate gas washout indices: Assessment of ventilation inhomogeneity in mild to moderate pediatric cystic fibrosis lung disease.

Nyilas, Sylvia; Bigler, Anja; Yammine, Sophie; Kieninger, Elisabeth; Rochat, Isabelle; Ramsey, Kathryn; Casaulta, Carmen; Moeller, Alexander; Latzin, Philipp; Singer, Florian (2018). Alternate gas washout indices: Assessment of ventilation inhomogeneity in mild to moderate pediatric cystic fibrosis lung disease. Pediatric pulmonology, 53(11), pp. 1485-1491. Wiley-Blackwell 10.1002/ppul.24149

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INTRODUCTION

Normalized phase III slope (Sn ) indices from multiple breath washout (MBW) estimate ventilation inhomogeneity. Alternate (*) protocols for Sn indices exist, however the utility of these outcomes in children with mild-to-moderate cystic fibrosis (CF) is unknown.

METHODS

We measured nitrogen MBW and spirometry in 135 children (43 controls) aged 4-18 years. We assessed validity, practicability, and reliability of Sn protocols. Outcomes included the ability to detect abnormal lung function, test agreement, measurement duration, intra-test repeatability, and quality.

RESULTS

Lung clearance index (LCI) was abnormal in 80 (87%), Scond in 55 (60%), Scond* in 17 (19%), Sacin in 10 (11%), Sacin* in 11 (12%), and FEV in 28 (30%). Alternate protocols reduced measurement duration. Agreement of indices to detect abnormal lung function was poor. The quality of analysis and repeatability deteriorated with the alternate technique compared to standard.

CONCLUSION

In children with mild-to-moderate CF lung disease, alternate protocols seem practical but clinimetric properties of standard Sn protocols are preferable.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Nyilas, Sylvia Meryl, Bigler, Anja, Yammine, Sophie, Kieninger, Elisabeth, Ramsey, Kathryn Angela, Casaulta, Carmen, Latzin, Philipp, Singer, Florian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

8755-6863

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

09 Jan 2019 11:34

Last Modified:

05 Dec 2022 15:18

Publisher DOI:

10.1002/ppul.24149

PubMed ID:

30168294

Uncontrolled Keywords:

child cystic fibrosis lung function tests

BORIS DOI:

10.7892/boris.120754

URI:

https://boris.unibe.ch/id/eprint/120754

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