Infant multiple breath washout using a new commercially available device: Ready to replace the previous setup?

Kentgens, Anne-Christianne; Guidi, Marisa; Korten, Insa; Kohler, Lena; Binggeli, Severin; Singer, Florian; Latzin, Philipp; Anagnostopoulou, Pinelopi (2018). Infant multiple breath washout using a new commercially available device: Ready to replace the previous setup? Pediatric pulmonology, 53(5), pp. 628-635. Wiley-Blackwell 10.1002/ppul.23959

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INTRODUCTION Multiple breath washout (MBW) is a sensitive test to measure lung volumes and ventilation inhomogeneity from infancy on. The commonly used setup for infant MBW, based on ultrasonic flowmeter, requires extensive signal processing, which may reduce robustness. A new setup may overcome some previous limitations but formal validation is lacking. AIM We assessed the feasibility of infant MBW testing with the new setup and compared functional residual capacity (FRC) values of the old and the new setup in vivo and in vitro. METHODS We performed MBW in four healthy infants and four infants with cystic fibrosis, as well as in a Plexiglas lung simulator using realistic lung volumes and breathing patterns, with the new (Exhalyzer D, Spiroware 3.2.0, Ecomedics) and the old setup (Exhalyzer D, WBreath 3.18.0, ndd) in random sequence. RESULTS The technical feasibility of MBW with the new device-setup was 100%. Intra-subject variability in FRC was low in both setups, but differences in FRC between the setups were considerable (mean relative difference 39.7%, range 18.9; 65.7, P = 0.008). Corrections of software settings decreased FRC differences (14.0%, -6.4; 42.3, P = 0.08). Results were confirmed in vitro. CONCLUSION MBW measurements with the new setup were feasible in infants. However, despite attempts to correct software settings, outcomes between setups were not interchangeable. Further work is needed before widespread application of the new setup can be recommended.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Kentgens, Anne-Christianne; Korten, Insa Christina Severine; Binggeli, Severin; Singer, Florian; Latzin, Philipp and Anagnostopoulou, Pinelopi

Subjects:

600 Technology > 610 Medicine & health

ISSN:

8755-6863

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Romy Melanie Rodriguez Del Rio

Date Deposited:

09 Jan 2019 11:40

Last Modified:

24 Oct 2019 16:13

Publisher DOI:

10.1002/ppul.23959

PubMed ID:

29418075

Uncontrolled Keywords:

functional residual capacity infant lung function multiple breath washout ultrasonic flowmeter

BORIS DOI:

10.7892/boris.120762

URI:

https://boris.unibe.ch/id/eprint/120762

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