Genome-wide association study and heritability estimate for ectopic ureters in Entlebucher mountain dogs.

Gallana, M; Utsunomiya, Y T; Dolf, Gaudenz; Pintor Torrecilha, R B; Falbo, A-K; Jagannathan, Vidhya; Leeb, Tosso; Reichler, I; Sölkner, J; Schelling, C (2018). Genome-wide association study and heritability estimate for ectopic ureters in Entlebucher mountain dogs. Animal genetics, 49(6), pp. 645-650. Wiley 10.1111/age.12728

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An ectopic ureter is a congenital anomaly which may lead to urinary incontinence and without a surgical intervention even to end-stage kidney disease. A genetic component contributes to the development of this anomaly in Entlebucher mountain dogs (EMD); however, its nature remains unclear. Using the Illumina CanineHD bead chip, a case-control genome-wide association study was performed to identify SNPs associated with the trait. Six loci on canine chromosomes 3, 17, 27 and 30 were identified with 16 significantly associated SNPs. There was no single outstanding SNP associated with the phenotype, and the association signals were not close to known genes involved in human congenital anomalies of the kidney or lower urinary tract. Additional research will be necessary to elucidate the potential role of the associated genes in the development of ectopic ureters in the EMD breed.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Dolf, Gaudenz; Jagannathan, Vidya and Leeb, Tosso

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0268-9146

Publisher:

Wiley

Language:

English

Submitter:

Tosso Leeb

Date Deposited:

12 Nov 2018 10:52

Last Modified:

01 Jan 2020 02:30

Publisher DOI:

10.1111/age.12728

PubMed ID:

30276844

Uncontrolled Keywords:

Canis lupus familiaris congenital anomalies of the kidney and urinary tract congenital anomalies of the lower urinary tract congenital urological malformation genome-wide association study urinary tract development

BORIS DOI:

10.7892/boris.121081

URI:

https://boris.unibe.ch/id/eprint/121081

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