Rabies Diagnosis for Developing Countries

Dürr, Salome; Naïssengar, Service; Mindekem, Rolande; Diguimbye, Colette; Niezgoda, Michael; Kuzmin, Ivan; Rupprecht, Charles E.; Zinsstag, Jakob (2008). Rabies Diagnosis for Developing Countries. PLoS neglected tropical diseases, 2(3), e206. Public Library of Science 10.1371/journal.pntd.0000206

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A new diagnostic test for rabies in animals was evaluated in N'Djaména, capital of Chad. The test is based on a direct immuno-histochemical detection of rabies virus in brain tissue (dRIT) visible by normal light microscopy. Rabies detection by dRIT light microscopy is 10 times less expensive than fluorescence microscopy required for the current gold standard of rabies diagnosis. The test showed ideal results in fresh samples with 100% agreement with the gold standard and confirms the results of a first study in Tanzania. Thus, it has a significant potential for diagnosing rabies in low-income countries, and under field conditions where rabies diagnosis is unavailable for the moment. This new test opens up a great potential to train technical staff and to establish rabies diagnosis without delay in low-income countries with urban rabies.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Veterinary Public Health / Herd Health Management
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Dürr, Salome Esther

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

1935-2727

Publisher:

Public Library of Science

Language:

English

Submitter:

Salome Esther Dürr

Date Deposited:

21 Nov 2018 14:59

Last Modified:

24 Oct 2019 09:16

Publisher DOI:

10.1371/journal.pntd.0000206

PubMed ID:

18365035

BORIS DOI:

10.7892/boris.121191

URI:

https://boris.unibe.ch/id/eprint/121191

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