Rabies Diagnosis for Developing Countries

Dürr, Salome; Naïssengar, Service; Mindekem, Rolande; Diguimbye, Colette; Niezgoda, Michael; Kuzmin, Ivan; Rupprecht, Charles E.; Zinsstag, Jakob (2008). Rabies Diagnosis for Developing Countries. PLoS neglected tropical diseases, 2(3), e206. Public Library of Science 10.1371/journal.pntd.0000206

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A new diagnostic test for rabies in animals was evaluated in N'Djaména, capital of Chad. The test is based on a direct immuno-histochemical detection of rabies virus in brain tissue (dRIT) visible by normal light microscopy. Rabies detection by dRIT light microscopy is 10 times less expensive than fluorescence microscopy required for the current gold standard of rabies diagnosis. The test showed ideal results in fresh samples with 100% agreement with the gold standard and confirms the results of a first study in Tanzania. Thus, it has a significant potential for diagnosing rabies in low-income countries, and under field conditions where rabies diagnosis is unavailable for the moment. This new test opens up a great potential to train technical staff and to establish rabies diagnosis without delay in low-income countries with urban rabies.

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