Fatal bronchopneumonia caused by skunk adenovirus 1 in an African pygmy hedgehog.

Needle, David B; Selig, Martin K; Jackson, Kenneth A; Delwart, Eric; Tighe, Ellyn; Leib, Stephen L.; Seuberlich, Torsten; Pesavento, Patricia A (2019). Fatal bronchopneumonia caused by skunk adenovirus 1 in an African pygmy hedgehog. Journal of veterinary diagnostic investigation, 31(1), pp. 103-106. American Association of Veterinary Laboratory Diagnosticians AAVLD 10.1177/1040638718812123

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Eleven adult African pygmy hedgehogs ( Atelerix albiventris) were added to a group of 35 animals, and within 10 d, respiratory distress affected 8 of 35 resident animals in the group, but none of the introduced animals. Three animals died following onset of clinical signs. Tissues from one animal were collected and submitted for histopathology, which revealed acute necrotizing bronchopneumonia and tracheitis with intraepithelial intranuclear inclusion bodies. Electron microscopy identified 75-90 nm diameter encapsulated icosahedral virions. Degenerate nested PCR analysis identified adenovirus within the affected lung tissue. Deep sequencing showed 100% homology to skunk adenovirus 1 (SkAdV-1). Adenoviruses are usually species-adapted and -specific, but our case supports the single previous report of non-skunk infection with SkAdV-1, indicating that this virus can infect other species, and further shows that it can cause fatal disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Leib, Stephen and Seuberlich, Torsten

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1040-6387

Publisher:

American Association of Veterinary Laboratory Diagnosticians AAVLD

Language:

English

Submitter:

Stephen Leib

Date Deposited:

04 Dec 2018 11:52

Last Modified:

02 Nov 2019 22:54

Publisher DOI:

10.1177/1040638718812123

PubMed ID:

30475680

Uncontrolled Keywords:

Adenoviridae African pygmy hedgehogs Atelerix albiventris PCR bronchopneumonia, lung skunk adenovirus 1 transmission electron microscopy

BORIS DOI:

10.7892/boris.122026

URI:

https://boris.unibe.ch/id/eprint/122026

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