Xenacoelomorpha Survey Reveals That All 11 Animal Homeobox Gene Classes Were Present in the First Bilaterians

Brauchle, Michael Anton; Bilican, Adem; Eyer, Claudia; Bailly, X; Martinez, P; Ladurner, P; Bruggmann, Rémy; Sprecher, SG (2018). Xenacoelomorpha Survey Reveals That All 11 Animal Homeobox Gene Classes Were Present in the First Bilaterians. Genome biology and evolution, 10(9), pp. 2205-2217. Oxford University Press 10.1093/gbe/evy170

[img]
Preview
Text
evy170(1).pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC).

Download (1MB) | Preview

Homeodomain transcription factors are involved in many developmental processes across animals and have been linked to body plan evolution. Detailed classifications of these proteins identified 11 distinct classes of homeodomain proteins in animal genomes, each harboring specific sequence composition and protein domains. Although humans contain the full set of classes, Drosophila melanogaster and Caenorhabditis elegans each lack one specific class. Furthermore, representative previous analyses in sponges, ctenophores, and cnidarians could not identify several classes in those nonbilaterian metazoan taxa. Consequently, it is currently unknown when certain homeodomain protein classes first evolved during animal evolution. Here, we investigate representatives of the sister group to all remaining bilaterians, the Xenacoelomorpha. We analyzed three acoel, one nemertodermatid, and one Xenoturbella transcriptomes and identified their expressed homeodomain protein content. We report the identification of representatives of all 11 classes of animal homeodomain transcription factors in Xenacoelomorpha and we describe and classify their homeobox genes relative to the established animal homeodomain protein families. Our findings suggest that the genome of the last common ancestor of bilateria contained the full set of these gene classes, supporting the subsequent diversification of bilaterians.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Brauchle, Michael Anton; Bilican, Adem; Eyer, Claudia and Bruggmann, Rémy

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)

ISSN:

1759-6653

Publisher:

Oxford University Press

Language:

English

Submitter:

Dr Michael Anton Brauchle

Date Deposited:

27 Dec 2018 14:38

Last Modified:

27 Dec 2018 14:38

Publisher DOI:

10.1093/gbe/evy170

BORIS DOI:

10.7892/boris.122192

URI:

https://boris.unibe.ch/id/eprint/122192

Actions (login required)

Edit item Edit item
Provide Feedback