IgA Function in Relation to the Intestinal Microbiota.

Macpherson, Andrew; Yilmaz, Bahtiyar; Limenitakis, Julien Periclis Jean; Ganal-Vonarburg, Stephanie (2018). IgA Function in Relation to the Intestinal Microbiota. Annual review of immunology, 36, pp. 359-381. Annual Reviews 10.1146/annurev-immunol-042617-053238

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IgA is the dominant immunoglobulin isotype produced in mammals, largely secreted across the intestinal mucosal surface. Although induction of IgA has been a hallmark feature of microbiota colonization following colonization in germ-free animals, until recently appreciation of the function of IgA in host-microbial mutualism has depended mainly on indirect evidence of alterations in microbiota composition or penetration of microbes in the absence of somatic mutations in IgA (or compensatory IgM). Highly parallel sequencing techniques that enable high-resolution analysis of either microbial consortia or IgA sequence diversity are now giving us new perspectives on selective targeting of microbial taxa and the trajectory of IgA diversification according to induction mechanisms, between different individuals and over time. The prospects are to link the range of diversified IgA clonotypes to specific antigenic functions in modulating the microbiota composition, position and metabolism to ensure host mutualism.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Macpherson, Andrew; Yilmaz, Bahtiyar; Limenitakis, Julien Periclis Jean and Ganal-Vonarburg, Stephanie

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1545-3278

Publisher:

Annual Reviews

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

22 Jan 2019 08:46

Last Modified:

22 Jan 2019 08:46

Publisher DOI:

10.1146/annurev-immunol-042617-053238

PubMed ID:

29400985

Uncontrolled Keywords:

IgA antibody binding childhood enteropathy early-life immunity immunoglobulin repertoire intestinal inflammation microbiota

BORIS DOI:

10.7892/boris.122387

URI:

https://boris.unibe.ch/id/eprint/122387

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