IgA Function in Relation to the Intestinal Microbiota.

Macpherson, Andrew; Yilmaz, Bahtiyar; Limenitakis, Julien Periclis Jean; Ganal-Vonarburg, Stephanie (2018). IgA Function in Relation to the Intestinal Microbiota. Annual review of immunology, 36, pp. 359-381. Annual Reviews 10.1146/annurev-immunol-042617-053238

Text annurev-immunol-042617-053238.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB) | Request a copy

IgA is the dominant immunoglobulin isotype produced in mammals, largely secreted across the intestinal mucosal surface. Although induction of IgA has been a hallmark feature of microbiota colonization following colonization in germ-free animals, until recently appreciation of the function of IgA in host-microbial mutualism has depended mainly on indirect evidence of alterations in microbiota composition or penetration of microbes in the absence of somatic mutations in IgA (or compensatory IgM). Highly parallel sequencing techniques that enable high-resolution analysis of either microbial consortia or IgA sequence diversity are now giving us new perspectives on selective targeting of microbial taxa and the trajectory of IgA diversification according to induction mechanisms, between different individuals and over time. The prospects are to link the range of diversified IgA clonotypes to specific antigenic functions in modulating the microbiota composition, position and metabolism to ensure host mutualism.

Interest & Impact

Downloads

3 since deposited on 22 Jan 2019
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item