The utility of an RDoC motor domain to understand psychomotor symptoms in depression

Walther, Sebastian; Bernard, J A; Mittal, V A; Shankman, S A (2019). The utility of an RDoC motor domain to understand psychomotor symptoms in depression. Psychological medicine, 49(2), pp. 212-216. Cambridge University Press 10.1017/S0033291718003033

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Despite the clinical impact of motor symptoms such as agitation or retardation on the course of depression, these symptoms are poorly understood. Novel developments in the field of instrumentation and mobile devices allow for dimensional and continuous recording of motor behavior in various settings, particularly outside the laboratory. Likewise, the use of novel assessments enables to combine multimodal neuroimaging with behavioral measures in order to investigate the neural correlates of motor dysfunction in depression. The research domain criteria (RDoC) framework will soon include a motor domain that will provide a framework for studying motor dysfunction in mood disorders. In addition, new studies within this framework will allow investigators to study motor symptoms across different stages of depression as well as other psychiatric diagnoses. Finally, the introduction of the RDoC motor domain will help test how motor symptoms integrate with the original five RDoC domains (negative valence, positive valence, cognitive, social processes, and arousal/regulation).

Item Type:

Journal Article (Further Contribution)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Walther, Sebastian


600 Technology > 610 Medicine & health




Cambridge University Press




Sebastian Walther

Date Deposited:

23 Jan 2019 16:33

Last Modified:

21 Nov 2019 04:12

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Brain circuits RDoC motor behavior transdiagnostic




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