The interleukin 4 receptor gene and its role in recurrent airway obstruction in Swiss Warmblood horses

Klukowska-Rötzler, Jolanta; Swinburne, J.E.; Drögemüller, Cord; Dolf, Gaudenz; Janda, Jozef; Leeb, Tosso; Gerber, Vinzenz (2012). The interleukin 4 receptor gene and its role in recurrent airway obstruction in Swiss Warmblood horses. Animal genetics, 43(4), pp. 450-453. Oxford: Blackwell 10.1111/j.1365-2052.2011.02277.x

[img] Text
j.1365-2052.2011.02277.x.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (140kB) | Request a copy

Recurrent airway obstruction (RAO) in horses is the result of an interaction of genetic and environmental factors and shares many characteristics with human asthma. Many studies have suggested that the interleukin-4 receptor gene (IL4R) is associated with this disease, and a QTL region on chromosome 13 containing IL4R was previously detected in one of the two Swiss Warmblood families. We sequenced the entire IL4R gene in this family and detected 93 variants including five non-synonymous protein-coding variants. The allele distribution at these SNPs supported the previously detected QTL signal. Subsequently, we investigated IL4R mRNA expression in bronchoalveolar lavage fluid cells. During exacerbation, IL4R expression was increased in RAO-affected offspring in the implicated family, but not in the other family. These findings support that IL4R plays a role in some cases of RAO.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Klukowska, Jolanta; Drögemüller, Cord; Dolf, Gaudenz; Janda, Jozef; Leeb, Tosso and Gerber, Vinzenz

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

0268-9146

Publisher:

Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

10 Aug 2015 13:37

Publisher DOI:

10.1111/j.1365-2052.2011.02277.x

PubMed ID:

22497430

Web of Science ID:

000306122200012

BORIS DOI:

10.7892/boris.12273

URI:

https://boris.unibe.ch/id/eprint/12273 (FactScience: 218589)

Actions (login required)

Edit item Edit item
Provide Feedback