Fundamental characterization of conductive intracardiac communication for leadless multisite pacemaker systems

Bereuter, Lukas David; Kuenzle, Timon; Niederhauser, Thomas; Kucera, Martin; Obrist, Dominik; Reichlin, Tobias Roman; Tanner, Hildegard; Haeberlin, Andreas (2019). Fundamental characterization of conductive intracardiac communication for leadless multisite pacemaker systems. IEEE transactions on biomedical circuits and systems, 13(1), pp. 237-247. Institute of Electrical and Electronics Engineers IEEE 10.1109/TBCAS.2018.2886042

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Objective: A new generation of leadless cardiac pacemakers effectively overcomes the main limitations of conventional devices, but only offer single-chamber pacing, although dual-chamber or multisite pacing is highly desirable for most patients. The combination of several leadless pacemakers could facilitate a leadless multisite pacemaker but requires an energy-efficient wireless communication for device synchronization. This work investigates the characteristics of conductive intracardiac communication between leadless pacemakers to provide a basis for future designs of leadless multisite pacemaker systems. Methods: Signal propagation and impedance behavior of blood and heart tissue were examined by in vitro and in vivo measurements on domestic pig hearts and by finite-element simulations in the frequency range of 1 kHz-1 MHz. Results: A better signal transmission was obtained for frequencies higher than 10 kHz. The influence of a variety of practical parameters on signal transmission could be identified. A larger distance between pacemakers increases signal attenuation. A better signal transmission is obtained through larger inter-electrode distances and a larger electrode surface area. Furthermore, the influence of pacemaker encapsulation and relative device orientation was assessed. Conclusion: This study suggests that conductive intracardiac communication is well suited to be incorporated in leadless pacemakers. It potentially offers very low power consumption using low communication frequencies. Significance: The presented technique enables highly desired leadless multisite pacing in near future.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology 04 Faculty of Medicine > Faculty Institutions > sitem Center for Translational Medicine and Biomedical Entrepreneurship > Cardiac Technology and Implantable Devices 04 Faculty of Medicine > Faculty Institutions > sitem Center for Translational Medicine and Biomedical Entrepreneurship 10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research 10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE)
Graduate School:	Graduate School for Cellular and Biomedical Sciences (GCB)
UniBE Contributor:	Bereuter, Lukas David, Niederhauser, Thomas, Obrist, Dominik, Reichlin, Tobias Roman, Tanner, Hildegard, Häberlin, Andreas David Heinrich
Subjects:	600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology 600 Technology > 620 Engineering
ISSN:	1932-4545
Publisher:	Institute of Electrical and Electronics Engineers IEEE
Language:	English
Submitter:	Lukas David Bereuter
Date Deposited:	04 Feb 2019 08:38
Last Modified:	05 Dec 2022 15:23
Publisher DOI:	10.1109/TBCAS.2018.2886042
PubMed ID:	30530338
URI:	https://boris.unibe.ch/id/eprint/122886