Fundamental characterization of conductive intracardiac communication for leadless multisite pacemaker systems

Bereuter, Lukas David; Kuenzle, Timon; Niederhauser, Thomas; Kucera, Martin; Obrist, Dominik; Reichlin, Tobias Roman; Tanner, Hildegard; Häberlin, Andreas (2019). Fundamental characterization of conductive intracardiac communication for leadless multisite pacemaker systems. IEEE transactions on biomedical circuits and systems, 13(1), pp. 237-247. Institute of Electrical and Electronics Engineers IEEE 10.1109/TBCAS.2018.2886042

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Objective: A new generation of leadless cardiac pacemakers effectively overcomes the main limitations of conventional devices, but only offer single-chamber pacing, although dual-chamber or multisite pacing is highly desirable for most patients. The combination of several leadless pacemakers could facilitate a leadless multisite pacemaker but requires an energy-efficient wireless communication for device synchronization. This work investigates the characteristics of conductive intracardiac communication between leadless pacemakers to provide a basis for future designs of leadless multisite pacemaker systems. Methods: Signal propagation and impedance behavior of blood and heart tissue were examined by in vitro and in vivo measurements on domestic pig hearts and by finite-element simulations in the frequency range of 1 kHz-1 MHz. Results: A better signal transmission was obtained for frequencies higher than 10 kHz. The influence of a variety of practical parameters on signal transmission could be identified. A larger distance between pacemakers increases signal attenuation. A better signal transmission is obtained through larger inter-electrode distances and a larger electrode surface area. Furthermore, the influence of pacemaker encapsulation and relative device orientation was assessed. Conclusion: This study suggests that conductive intracardiac communication is well suited to be incorporated in leadless pacemakers. It potentially offers very low power consumption using low communication frequencies. Significance: The presented technique enables highly desired leadless multisite pacing in near future.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE)
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Bereuter, Lukas David; Niederhauser, Thomas; Obrist, Dominik; Reichlin, Tobias Roman; Tanner, Hildegard and Häberlin, Andreas

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

ISSN:

1932-4545

Publisher:

Institute of Electrical and Electronics Engineers IEEE

Language:

English

Submitter:

Lukas David Bereuter

Date Deposited:

04 Feb 2019 08:38

Last Modified:

04 Feb 2019 08:38

Publisher DOI:

10.1109/TBCAS.2018.2886042

PubMed ID:

30530338

URI:

https://boris.unibe.ch/id/eprint/122886

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