The Prospects of an Active Vaccine Against Asthma Targeting IL-5.

Bachmann, Martin; El-Turabi, Aadil; Fettelschoss-Gabriel, Antonia; Vogel, Monique (2018). The Prospects of an Active Vaccine Against Asthma Targeting IL-5. Frontiers in Microbiology, 9(2522), p. 2522. Frontiers 10.3389/fmicb.2018.02522

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Allergen-specific T helper type 2 (Th2) responses followed by eosinophilic inflammation of the lung are important causes of allergic asthma. Interleukin-5 (IL-5) is a master regulator of eosinophil differentiation as well as activation. Blocking IL-5 using monoclonal antibodies (mAbs) against IL-5 is a powerful way to improve asthmatic symptoms in patients with an eosinophilic component of the disease. We have previously shown that vaccination against IL-5 can abrogate eosinophilic inflammation of the lung in allergic mice. More recently, we have demonstrated that eosinophil-mediated skin disease in horses with insect bite hypersensitivity can be strongly reduced by vaccination against IL-5. Here we would like to propose the development of a similar vaccine for the treatment of asthma in humans.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Bachmann, Martin and Vogel, Monique

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-302X

Publisher:

Frontiers

Language:

English

Submitter:

Valery Beer

Date Deposited:

31 Jan 2019 11:13

Last Modified:

03 Feb 2019 02:35

Publisher DOI:

10.3389/fmicb.2018.02522

PubMed ID:

30405579

Uncontrolled Keywords:

IL-5 asthma cytokine vaccination vaccine virus-like particle

BORIS DOI:

10.7892/boris.122896

URI:

https://boris.unibe.ch/id/eprint/122896

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