Bachmann, Martin; El-Turabi, Aadil; Fettelschoss-Gabriel, Antonia; Vogel, Monique (2018). The Prospects of an Active Vaccine Against Asthma Targeting IL-5. Frontiers in Microbiology, 9(2522), p. 2522. Frontiers 10.3389/fmicb.2018.02522
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Allergen-specific T helper type 2 (Th2) responses followed by eosinophilic inflammation of the lung are important causes of allergic asthma. Interleukin-5 (IL-5) is a master regulator of eosinophil differentiation as well as activation. Blocking IL-5 using monoclonal antibodies (mAbs) against IL-5 is a powerful way to improve asthmatic symptoms in patients with an eosinophilic component of the disease. We have previously shown that vaccination against IL-5 can abrogate eosinophilic inflammation of the lung in allergic mice. More recently, we have demonstrated that eosinophil-mediated skin disease in horses with insect bite hypersensitivity can be strongly reduced by vaccination against IL-5. Here we would like to propose the development of a similar vaccine for the treatment of asthma in humans.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology |
UniBE Contributor: |
Bachmann, Martin (B), Vogel, Monique |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1664-302X |
Publisher: |
Frontiers |
Language: |
English |
Submitter: |
Valery Beer |
Date Deposited: |
31 Jan 2019 11:13 |
Last Modified: |
29 Mar 2023 23:36 |
Publisher DOI: |
10.3389/fmicb.2018.02522 |
PubMed ID: |
30405579 |
Uncontrolled Keywords: |
IL-5 asthma cytokine vaccination vaccine virus-like particle |
BORIS DOI: |
10.7892/boris.122896 |
URI: |
https://boris.unibe.ch/id/eprint/122896 |
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