Advances in therapeutic options for portal hypertension.

Vilaseca, Marina; Guixé Muntet, Sergi; Fernández-Iglesias, Anabel; Gracia-Sancho, Jordi (2018). Advances in therapeutic options for portal hypertension. Therapeutic advances in gastroenterology, 11, p. 1756284818811294. Sage 10.1177/1756284818811294

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Portal hypertension represents one of the major clinical consequences of chronic liver disease, having a deep impact on patients' prognosis and survival. Its pathophysiology defines a pathological increase in the intrahepatic vascular resistance as the primary factor in its development, being subsequently aggravated by a paradoxical increase in portal blood inflow. Although extensive preclinical and clinical research in the field has been developed in recent decades, no effective treatment targeting its primary mechanism has been defined. The present review critically summarizes the current knowledge in portal hypertension therapeutics, focusing on those strategies driven by the disease pathophysiology and underlying cellular mechanisms.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Guixé Muntet, Sergi

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1756-283X

Publisher:

Sage

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

04 Feb 2019 08:05

Last Modified:

23 Oct 2019 02:00

Publisher DOI:

10.1177/1756284818811294

PubMed ID:

30505350

Uncontrolled Keywords:

HVPG cirrhosis hepatic hemodynamic portal pressure sinusoid

BORIS DOI:

10.7892/boris.122960

URI:

https://boris.unibe.ch/id/eprint/122960

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