Targeting IgE in allergic disease.

Gasser, Pascal; Eggel, Alexander (2018). Targeting IgE in allergic disease. Current opinion in immunology, 54, pp. 86-92. Elsevier 10.1016/j.coi.2018.05.015

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Immunoglobulin E (IgE) represents the least abundant antibody isotype in human serum. Nevertheless, it has the ability to induce potent allergic reactions. As a key component in the development and manifestation of hypersensitivity responses against usually non-hazardous foreign substances, IgE has become a major target of investigation and the subject of multiple therapeutic approaches for the treatment of allergies. Recent advances in the understanding of pathophysiologic mechanisms underlying IgE-associated allergic disorders have led to the generation of new drug candidates that are currently in development or under clinical evaluation. In this review, we highlight molecular and structural mechanisms underlying the different anti-IgE molecules and suggest a concept of multi-level targeting using a new class of disruptive IgE inhibitors to potentially optimize treatment efficacy.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Gasser, Pascal, Eggel, Alexander

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0952-7915

Publisher:

Elsevier

Language:

English

Submitter:

Valery Beer

Date Deposited:

08 Jan 2019 15:46

Last Modified:

05 Dec 2022 15:23

Publisher DOI:

10.1016/j.coi.2018.05.015

PubMed ID:

29986302

BORIS DOI:

10.7892/boris.122990

URI:

https://boris.unibe.ch/id/eprint/122990

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