Standardization in host-microbiota interaction studies: challenges, gnotobiology as a tool, and perspective.

Mooser, Catherine; Gomez de Agüero Tamargo, Maria de la Mercedes; Ganal-Vonarburg, Stephanie (2018). Standardization in host-microbiota interaction studies: challenges, gnotobiology as a tool, and perspective. Current opinion in microbiology, 44, pp. 50-60. Elsevier 10.1016/j.mib.2018.07.007

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Considering the increasing list of diseases linked to the commensal microbiota, experimental studies of host-microbe interactions are of growing interest. Axenic and differently colonized animal models are inalienable tools to study these interactions. Factors, such as host genetics, diet, antibiotics and litter affect microbiota composition and can be confounding factors in many experimental settings. The use of gnotobiotic mice harboring defined microbiotas of different complexity plus additional housing standardization have thus become a gold standard to study the influence of the microbiome on the host. We highlight here the recent advances, challenges and outstanding goals in gnotobiology with the ambition to contribute to the generation of reliable, reproducible and transferrable results, which form the basis for advances in biomedical research.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Mooser, Catherine; Gomez de Agüero Tamargo, Maria de la Mercedes and Ganal-Vonarburg, Stephanie

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1879-0364

Publisher:

Elsevier

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

04 Feb 2019 09:24

Last Modified:

04 Feb 2019 09:24

Publisher DOI:

10.1016/j.mib.2018.07.007

PubMed ID:

30056329

BORIS DOI:

10.7892/boris.122992

URI:

https://boris.unibe.ch/id/eprint/122992

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