Comparison of contemporary staging systems for oropharynx cancer in a surgically treated multi-institutional cohort.

Eliçin, Olgun; Broglie, Martina A; Fankhauser, Niklaus; Stoeckli, Sandro J; Pasche, Philippe; Reinhard, Antoine; Bongiovanni, Massimo; Huber, Gerhard F; Morand, Grégoire B; Soltermann, Alex; Arnold, Andreas; Dettmer, Matthias S; Arnoux, André; Stauffer, Edouard; Espeli, Vittoria; Martucci, Francesco; Aebersold, Daniel; Giger, Roland M (2019). Comparison of contemporary staging systems for oropharynx cancer in a surgically treated multi-institutional cohort. Head & neck - journal for the sciences and specialties of the head and neck, 41(5), pp. 1395-1402. J. Wiley 10.1002/hed.25574

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BACKGROUND

Between the publication of the Union of International Cancer Control staging system (UICC) 7th and 8th editions, other staging algorithms for oropharyngeal squamous cell carcinoma (OPSCC) were proposed from Radiation Therapy Oncology Group (RTOG), MD Anderson Cancer Center (MDACC), and Yale University.

METHODS

With C-statistics, the above-mentioned five staging algorithms were compared for overall and relapse-free survival endpoints in a multi-institutional cohort of OPSCC cases (n = 338) treated with primary surgery.

RESULTS

Pathological UICC 8th ed yielded the highest C-indexes in the entire cohort and in the HPV- subset, whereas MDACC was superior for HPV+ OPSCC. RTOG was the simplest and holistic algorithm with a noninferior discriminatory power.

CONCLUSION

UICC 8th ed, MDACC, and RTOG offer moderate and comparable efficacy for staging in this OPSCC patient cohort undergoing surgical treatment. Notable discrepancy between clinical and pathological UICC 8th ed algorithms poses potential concerns in diagnosis, treatment, research, and data management.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR)

UniBE Contributor:

 Eliçin, Olgun, Fankhauser, Niklaus, Arnold, Andreas Michael, Dettmer, Matthias, Aebersold, Daniel Matthias, Giger, Roland

Subjects:

 600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

 1043-3074

Publisher:

 J. Wiley

Language:

 English

Submitter:

 Tanya Karrer

Date Deposited:

 17 Jan 2019 19:51

Last Modified:

 20 Feb 2024 14:16

Publisher DOI:

 10.1002/hed.25574

PubMed ID:

 30593685

Uncontrolled Keywords:

 cancer staging head and neck cancer human papillomavirus oropharynx cancer surgery

BORIS DOI:

 10.7892/boris.123515

URI:

 https://boris.unibe.ch/id/eprint/123515

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