Comparison of contemporary staging systems for oropharynx cancer in a surgically treated multi-institutional cohort.

Eliçin, Olgun; Broglie, Martina A; Fankhauser, Niklaus; Stoeckli, Sandro J; Pasche, Philippe; Reinhard, Antoine; Bongiovanni, Massimo; Huber, Gerhard F; Morand, Grégoire B; Soltermann, Alex; Arnold, Andreas; Dettmer, Matthias S; Arnoux, André; Stauffer, Edouard; Espeli, Vittoria; Martucci, Francesco; Aebersold, Daniel; Giger, Roland M (2019). Comparison of contemporary staging systems for oropharynx cancer in a surgically treated multi-institutional cohort. Head & neck - journal for the sciences and specialties of the head and neck, 41(5), pp. 1395-1402. J. Wiley 10.1002/hed.25574

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BACKGROUND

Between the publication of the Union of International Cancer Control staging system (UICC) 7th and 8th editions, other staging algorithms for oropharyngeal squamous cell carcinoma (OPSCC) were proposed from Radiation Therapy Oncology Group (RTOG), MD Anderson Cancer Center (MDACC), and Yale University.

METHODS

With C-statistics, the above-mentioned five staging algorithms were compared for overall and relapse-free survival endpoints in a multi-institutional cohort of OPSCC cases (n = 338) treated with primary surgery.

RESULTS

Pathological UICC 8th ed yielded the highest C-indexes in the entire cohort and in the HPV- subset, whereas MDACC was superior for HPV+ OPSCC. RTOG was the simplest and holistic algorithm with a noninferior discriminatory power.

CONCLUSION

UICC 8th ed, MDACC, and RTOG offer moderate and comparable efficacy for staging in this OPSCC patient cohort undergoing surgical treatment. Notable discrepancy between clinical and pathological UICC 8th ed algorithms poses potential concerns in diagnosis, treatment, research, and data management.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology 04 Faculty of Medicine > Service Sector > Institute of Pathology 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) 04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR)
UniBE Contributor:	Eliçin, Olgun, Fankhauser, Niklaus, Arnold, Andreas Michael, Dettmer, Matthias, Aebersold, Daniel Matthias, Giger, Roland
Subjects:	600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology 300 Social sciences, sociology & anthropology > 360 Social problems & social services
ISSN:	1043-3074
Publisher:	J. Wiley
Language:	English
Submitter:	Tanya Karrer
Date Deposited:	17 Jan 2019 19:51
Last Modified:	20 Feb 2024 14:16
Publisher DOI:	10.1002/hed.25574
PubMed ID:	30593685
Uncontrolled Keywords:	cancer staging head and neck cancer human papillomavirus oropharynx cancer surgery
BORIS DOI:	10.7892/boris.123515
URI:	https://boris.unibe.ch/id/eprint/123515

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