Association Between Residual Inhibition and Neural Activity in Patients with Tinnitus: Protocol for a Controlled Within- and Between-Subject Comparison Study.

Hu, Suyi; Anschütz, Lukas Peter; Huth, Markus; Sznitman, Raphael; Blaser, Daniela; Kompis, Martin; Hall, Deborah A; Caversaccio, Marco; Wimmer, Wilhelm (2019). Association Between Residual Inhibition and Neural Activity in Patients with Tinnitus: Protocol for a Controlled Within- and Between-Subject Comparison Study. JMIR research protocols, 8(1), e12270. JMIR Publications 10.2196/12270

[img]
Preview
Text
2f49d436-43c6-4988-b4f7-4be0d917373d.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (670kB) | Preview

BACKGROUND Electroencephalography (EEG) studies indicate possible associations between tinnitus and changes in the neural activity. However, inconsistent results require further investigation to better understand such heterogeneity and inform the interpretation of previous findings. OBJECTIVE This study aims to investigate the feasibility of EEG measurements as an objective indicator for the identification of tinnitus-associated neural activities. METHODS To reduce heterogeneity, participants served as their own control using residual inhibition (RI) to modulate the tinnitus perception in a within-subject EEG study design with a tinnitus group. In addition, comparison with a nontinnitus control group allowed for a between-subjects comparison. We will apply RI stimulation to generate tinnitus and nontinnitus conditions in the same subject. Furthermore, high-frequency audiometry (up to 13 kHz) and tinnitometry will be performed. RESULTS This work was funded by the Infrastructure Grant of the University of Bern, Bern, Switzerland and Bernafon AG, Bern, Switzerland. Enrollment for the study described in this protocol commenced in February 2018. Data analysis is currently under way and the first results are expected to be submitted for publication in 2019. CONCLUSIONS This study design helps in comparing the neural activity between conditions in the same individual, thereby addressing a notable limitation of previous EEG tinnitus studies. In addition, the high-frequency assessment will help to analyze and classify tinnitus symptoms beyond the conventional clinical standard. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID) RR1-10.2196/12270.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Image Guided Therapy > ARTORG Center - Artificial Hearing Research
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Image Guided Therapy > ARTORG Center - Ophthalmic Technology Lab

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Hu, Suyi; Anschütz, Lukas Peter; Huth, Markus; Sznitman, Raphael; Blaser, Daniela; Kompis, Martin; Caversaccio, Marco and Wimmer, Wilhelm

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1929-0748

Publisher:

JMIR Publications

Language:

English

Submitter:

Wilhelm Wimmer

Date Deposited:

05 Feb 2019 11:10

Last Modified:

05 Feb 2019 11:10

Publisher DOI:

10.2196/12270

PubMed ID:

30626571

Uncontrolled Keywords:

electroencephalography heterogeneity high-frequency audiometry neural activity tinnitometry tinnitus

BORIS DOI:

10.7892/boris.123623

URI:

https://boris.unibe.ch/id/eprint/123623

Actions (login required)

Edit item Edit item
Provide Feedback