Morina, R.; Knorr, C.; Haase, Bianca; Leeb, Tosso; Seuberlich, Torsten; Zurbriggen, Andreas; Brem, G.; Schutz, E.; Brenig, B. (2010). Molecular analysis of carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) as a candidate gene for bovine spongiform encephalopathy susceptibility. Animal genetics, 41(1), pp. 85-8. Oxford: Blackwell 10.1111/j.1365-2052.2009.01951.x
Full text not available from this repository.Endogenous prion proteins (PrP) play the central role in the pathogenesis of transmissible spongiform encephalopathies. The carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) promotes the conversion of the cellular PrP(C) into the pathogenic PrP(d). Six sequence variants within the CHST8 gene were identified by comparative sequencing and genotyped for a sample of 623 animals comprising bovine spongiform encephalopathy (BSE)-affected and healthy control cows representing German Fleckvieh (German Simmental), German Holstein (Holstein-Friesian) and Brown Swiss. Significant differences in the allele, genotype and haplotype frequencies between BSE-affected and healthy cows indicate an association of sequence variant g.37254017G>T with the development of the disease in Brown Swiss cattle.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics |
UniBE Contributor: |
Haase, Bianca, Leeb, Tosso, Seuberlich, Torsten, Zurbriggen, Andreas (A) |
Subjects: |
500 Science > 590 Animals (Zoology) 600 Technology > 630 Agriculture |
ISSN: |
0268-9146 |
Publisher: |
Blackwell |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:32 |
Last Modified: |
29 Mar 2023 23:32 |
Publisher DOI: |
10.1111/j.1365-2052.2009.01951.x |
Web of Science ID: |
000273395600011 |
URI: |
https://boris.unibe.ch/id/eprint/12382 (FactScience: 218715) |
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