The severity of human peri-implantitis lesions correlates with the level of submucosal microbial dysbiosis.

Kröger, Annika; Hülsmann, Claudia; Fickl, Stefan; Spinell, Thomas; Hüttig, Fabian; Kaufmann, Frederic; Heimbach, André; Hoffmann, Per; Enkling, Norbert; Renvert, Stefan; Schwarz, Frank; Demmer, Ryan T; Papapanou, Panos N; Jepsen, Søren; Kebschull, Moritz (2018). The severity of human peri-implantitis lesions correlates with the level of submucosal microbial dysbiosis. Journal of clinical periodontology, 45(12), pp. 1498-1509. Wiley 10.1111/jcpe.13023

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AIM To cross-sectionally analyse the submucosal microbiome of peri-implantitis (PI) lesions at different severity levels. MATERIALS AND METHODS Microbial signatures of 45 submucosal plaque samples from untreated PI lesions obtained from 30 non-smoking, systemically healthy subjects were assessed by 16s sequencing. Linear mixed models were used to identify taxa with differential abundance by probing depth, after correction for age, gender, and multiple samples per subject. Network analyses were performed to identify groups of taxa with mutual occurrence or exclusion. Subsequently, the effects of peri-implant probing depth on submucosal microbial dysbiosis were calculated using the microbial dysbiosis index. RESULTS In total, we identified 337 different taxa in the submucosal microbiome of PI. Total abundance of 12 taxa correlated significantly with increasing probing depth; a significant relationship with lower probing depth was found for 16 taxa. Network analysis identified two mutually exclusive complexes associated with shallow pockets and deeper pockets, respectively. Deeper peri-implant pockets were associated with significantly increased dysbiosis. CONCLUSION Increases in peri-implant pocket depth are associated with substantial changes in the submucosal microbiome and increasing levels of dysbiosis.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Clinic of Reconstructive Dentistry and Gerodontology

UniBE Contributor:

Enkling, Norbert


600 Technology > 610 Medicine & health








Vanda Kummer

Date Deposited:

11 Mar 2019 10:34

Last Modified:

11 Mar 2019 10:34

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

16s dysbiosis microbiome next-generation sequencing peri-implant disease peri-implantitis




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