Wang, Yabo; Perentes, Jean Y; Schäfer, Stephan C; Gonzalez, Michel; Debefve, Elodie; Lehr, Hans-Anton; van den Bergh, Hubert; Krueger, Thorsten (2012). Photodynamic drug delivery enhancement in tumours does not depend on leukocyte-endothelial interaction in a human mesothelioma xenograft model. European journal of cardio-thoracic surgery, 42(2), pp. 348-54. Oxford: Oxford University Press 10.1093/ejcts/ezr294
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The pre-treatment of tumour neovessels by low-level photodynamic therapy (PDT) improves the distribution of concomitantly administered systemic chemotherapy. The mechanism by which PDT permeabilizes the tumour vessel wall is only partially known. We have recently shown that leukocyte-endothelial cell interaction is essential for photodynamic drug delivery to normal tissue. The present study investigates whether PDT enhances drug delivery in malignant mesothelioma and whether it involves comparable mechanisms of actions.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Schäfer, Stephan |
ISSN: |
1010-7940 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:32 |
Last Modified: |
14 Dec 2022 16:00 |
Publisher DOI: |
10.1093/ejcts/ezr294 |
PubMed ID: |
22290897 |
Web of Science ID: |
000306365600034 |
BORIS DOI: |
10.7892/boris.12446 |
URI: |
https://boris.unibe.ch/id/eprint/12446 (FactScience: 218790) |
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