Photodynamic drug delivery enhancement in tumours does not depend on leukocyte-endothelial interaction in a human mesothelioma xenograft model

Wang, Yabo; Perentes, Jean Y; Schäfer, Stephan C; Gonzalez, Michel; Debefve, Elodie; Lehr, Hans-Anton; van den Bergh, Hubert; Krueger, Thorsten (2012). Photodynamic drug delivery enhancement in tumours does not depend on leukocyte-endothelial interaction in a human mesothelioma xenograft model. European journal of cardio-thoracic surgery, 42(2), pp. 348-54. Oxford: Oxford University Press 10.1093/ejcts/ezr294

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The pre-treatment of tumour neovessels by low-level photodynamic therapy (PDT) improves the distribution of concomitantly administered systemic chemotherapy. The mechanism by which PDT permeabilizes the tumour vessel wall is only partially known. We have recently shown that leukocyte-endothelial cell interaction is essential for photodynamic drug delivery to normal tissue. The present study investigates whether PDT enhances drug delivery in malignant mesothelioma and whether it involves comparable mechanisms of actions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Schäfer, Stephan

ISSN:

1010-7940

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

27 Apr 2018 09:51

Publisher DOI:

10.1093/ejcts/ezr294

PubMed ID:

22290897

Web of Science ID:

000306365600034

BORIS DOI:

10.7892/boris.12446

URI:

https://boris.unibe.ch/id/eprint/12446 (FactScience: 218790)

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