Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection

Blasius, Amanda L.; Krebs, Philippe; Sullivan, Brian M.; Oldstone, Michael B.; Popkin, Daniel L. (2012). Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection. PLoS pathogens, 8(9), e1002915. San Francisco, Calif.: Public Library of Science 10.1371/journal.ppat.1002915

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Plasmacytoid dendritic cells (pDCs) are the major producers of type I IFN in response to viral infection and have been shown to direct both innate and adaptive immune responses in vitro. However, in vivo evidence for their role in viral infection is lacking. We evaluated the contribution of pDCs to acute and chronic virus infection using the feeble mouse model of pDC functional deficiency. We have previously demonstrated that feeble mice have a defect in TLR ligand sensing. Although pDCs were found to influence early cytokine secretion, they were not required for control of viremia in the acute phase of the infection. However, T cell priming was deficient in the absence of functional pDCs and the virus-specific immune response was hampered. Ultimately, infection persisted in feeble mice. We conclude that pDCs are likely required for efficient T cell priming and subsequent viral clearance. Our data suggest that reduced pDC functionality may lead to chronic infection.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology

UniBE Contributor:

Krebs, Philippe

ISSN:

1553-7366

Publisher:

Public Library of Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

13 Dec 2014 08:32

Publisher DOI:

10.1371/journal.ppat.1002915

PubMed ID:

23028315

Web of Science ID:

000309816500022

BORIS DOI:

10.7892/boris.12466

URI:

https://boris.unibe.ch/id/eprint/12466 (FactScience: 218811)

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