Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice

Wingender, Gerhard; Stepniak, Dariusz; Krebs, Philippe; Lin, Lin; McBride, Sara; Wei, Bo; Braun, Jonathan; Mazmanian, Sarkis K; Kronenberg, Mitchell (2012). Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice. Gastroenterology, 143(2), pp. 418-28. Philadelphia, Pa.: Elsevier 10.1053/j.gastro.2012.04.017

Full text not available from this repository. (Request a copy)

Invariant natural killer T (iNKT) cells undergo canonical, Vα14-Jα18 rearrangement of the T-cell receptor (TCR) in mice; this form of the TCR recognizes glycolipids presented by CD1d. iNKT cells mediate many different immune reactions. Their constitutive activated and memory phenotype and rapid initiation of effector functions after stimulation indicate previous antigen-specific stimulation. However, little is known about this process. We investigated whether symbiotic microbes can determine the activated phenotype and function of iNKT cells.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology

UniBE Contributor:

Krebs, Philippe

ISSN:

0016-5085

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

17 Mar 2015 21:20

Publisher DOI:

10.1053/j.gastro.2012.04.017

PubMed ID:

22522092

Web of Science ID:

000306661400033

URI:

https://boris.unibe.ch/id/eprint/12467 (FactScience: 218812)

Actions (login required)

Edit item Edit item
Provide Feedback