Sleep as a model to understand neuroplasticity and recovery after stroke: Observational, perturbational and interventional approaches

Mensen, Armand; Pigorini, A.; Facchin, Laura; Schöne, Cornelia; D'Ambrosio, S.; Jendoubi, J.; Jaramillo, V.; Chiffi, K.; Eberhard-Moscicka, Aleksandra K.; Sarasso, S.; Adamantidis, Antoine Roger; Müri, René Martin; Huber, R.; Massimini, M.; Bassetti, Claudio (2019). Sleep as a model to understand neuroplasticity and recovery after stroke: Observational, perturbational and interventional approaches. Journal of neuroscience methods, 313, pp. 37-43. Elsevier 10.1016/j.jneumeth.2018.12.011

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Our own experiences with disturbances to sleep demonstrate its crucial role in the recovery of cognitive functions. This importance is likely enhanced in the recovery from stroke; both in terms of its physiology and cognitive abilities. Decades of experimental research have highlighted which aspects and mechanisms of sleep are likely to underlie these forms of recovery. Conversely, damage to certain areas of the brain, as well as the indirect effects of stroke, may disrupt sleep. However, only limited research has been conducted which seeks to directly explore this bidirectional link between both the macro and micro-architecture of sleep and stroke. Here we describe a series of semi-independent approaches that aim to establish this link through observational, perturbational, and interventional experiments. Our primary aim is to describe the methodology for future clinical and translational research needed to delineate competing accounts of the current data. At the observational level we suggest the use of high-density EEG recording, combined analysis of macro and micro-architecture of sleep, detailed analysis of the stroke lesion, and sensitive measures of functional recovery. The perturbational approach attempts to find the causal links between sleep and stroke. We promote the use of transcranial magnetic stimulation combined with EEG to examine the cortical dynamics of the peri-infarct stroke area. Translational research should take this a step further using optogenetic techniques targeting more specific cell populations. The interventional approach focuses on how the same clinical and translational perturbational techniques can be adapted to influence long-term recovery of function.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie

UniBE Contributor:

Facchin, Laura; Schöne, Cornelia; Eberhard-Moscicka, Aleksandra Katarzyna; Adamantidis, Antoine Roger; Müri, René Martin and Bassetti, Claudio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0165-0270

Publisher:

Elsevier

Language:

English

Submitter:

Panagiota Milona

Date Deposited:

28 Jan 2019 16:39

Last Modified:

26 Jun 2019 15:42

Publisher DOI:

10.1016/j.jneumeth.2018.12.011

PubMed ID:

30571989

Uncontrolled Keywords:

Brain damage Eeg Functional recovery Sleep Slow waves Stroke Translational

BORIS DOI:

10.7892/boris.124739

URI:

https://boris.unibe.ch/id/eprint/124739

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