HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma

Piscuoglio, Salvatore; Zlobec, Inti; Pallante, Pierlorenzo; Sepe, Romina; Esposito, Francesco; Zimmermann, Arthur; Diamantis, Ioannis; Terracciano, Luigi; Fusco, Alfredo; Karamitopoulou, Eva (2012). HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma. Histopathology, 60(3), pp. 397-404. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2559.2011.04121.x

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Pancreatic ductal adenocarcinoma follows a multistep model of progression through precursor lesions called pancreatic intraepithelial neoplasia (PanIN). The high mobility group A1 (HMGA1) and high mobility group A2 (HMGA2) proteins are architectural transcription factors that have been implicated in the pathogenesis and progression of malignant tumours, including pancreatic cancer. The aim of this study was to explore the role of HMGA1 and HMGA2 in pancreatic carcinogenesis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Zlobec, Inti and Karamitopoulou, Evanthia

ISSN:

0309-0167

Publisher:

Blackwell Scientific Publications

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

17 Jul 2014 16:25

Publisher DOI:

10.1111/j.1365-2559.2011.04121.x

PubMed ID:

22276603

Web of Science ID:

000299553400002

URI:

https://boris.unibe.ch/id/eprint/12483 (FactScience: 218832)

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